A useful methoxyvinyl cation equivalent: α-t-butyldimethylsilyl-α-methoxyacetaldehyde.

Christopher D McCune, Matthew L Beio, Jacob A Friest, Sandeep Ginotra, David B Berkowitz

Abstract read

In one paragraph

Article in Tetrahedron letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Synthesis and Deployment of an Elusive Fluorovinyl Cation Equivalent: Access to Quaternary α-(1'-Fluoro)vinyl Amino Acids as Potential PLP Enzyme Inactivators.Journal of the American Chemical Society · 2017
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christopher D McCuneDepartment of Chemistry, University of Nebraska, Lincoln, NE 68588-0304, USA.

Matthew L BeioDepartment of Chemistry, University of Nebraska, Lincoln, NE 68588-0304, USA.

Jacob A FriestDepartment of Chemistry, University of Nebraska, Lincoln, NE 68588-0304, USA.

Sandeep GinotraDepartment of Chemistry, University of Nebraska, Lincoln, NE 68588-0304, USA.

David B BerkowitzDepartment of Chemistry, University of Nebraska, Lincoln, NE 68588-0304, USA.

Funding

EXTRAMURAL RES FACILITIES CONSTRC06RR016544 · NCRR · UNIVERSITY OF NEBRASKA LINCOLN · PI PAUL, PREM S · 2001 to 2001

$2.0M

NCRR NIH HHS C06 RR016544

6 · The paper itself

Abstract

Described are the synthesis and application of α-t-butyldimethylsilyl-α-methoxyacetaldehyde as a formal methoxyvinyl cation equivalent. Addition of Grignard reagents to the title aldehyde, followed by treatment of the intermediate β-hydroxysilanes with KH, gives good yields of large

Indexed as

chelation controlmethoxyvinylationPeterson eliminationsteric Felkin-Anh modelα-silyl-α-methoxyacetaldehyde

Identifiers

PMID26028786

DOI10.1016/j.tetlet.2015.02.122

PMCPMC4445900

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.