SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2015
Adverse childhood experience and asthma onset: a systematic review.
Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05731557 (ACE, Resilience, and Substance Use Disorder), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ACE, Resilience, and Substance Use Disorder: Maternal and Baby Outcomes in the First Year of Life
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Understanding adverse childhood experiences within the first decade of the ABCD study: A systematic review.Developmental cognitive neuroscience · 2026Pooled it
- Immune Tolerance vs. Immune Resistance: The Interaction Between Host and Pathogens in Infectious Diseases.Frontiers in veterinary science · 2022Pooled it
- Association between asthma and juvenile idiopathic arthritis in children in the United States: a propensity score weighted cross-sectional study.Pediatric rheumatology online journal · 2026Article
- Asthma prevalence, associated factors and role of adverse childhood experiences among school-going adolescents: the national School Health Survey in Togo (SHeST-study).BMJ open respiratory research · 2026Article
- Article
- The life course impact of adverse childhood experiences on chronic pulmonary disease: the roles of inflammatory response and social buffering.Innovation in aging · 2026Article
- Breathless Injustice: Association between Exposure To Racial Discrimination and Asthma Outcomes in Children.Journal of racial and ethnic health disparities · 2025Article
- Household dysfunction and child outcomes in the Nordic countries: A bibliometric analysis.Scandinavian journal of public health · 2025Review
- Trauma and Sensory Systems: Biological Mechanisms Involving the Skin and the 17q21 Gene Cluster.Biological psychiatry · 2025Review
- Resiliency in Child-Caregiver Dyads and the Impact on Health Outcomes in Sickle Cell Disease.Children (Basel, Switzerland) · 2025Article
- Article
- Defining and distinguishing early life stress, trauma, adversity, toxic and chronic stress and allostatic load: a descriptive review.Scandinavian journal of public health · 2024Review
- Impact of socioeconomic factors on allergic diseases.The Journal of allergy and clinical immunology · 2024Review
- Birthing parent adverse childhood experiences and risk of atopic diseases in 5-year-old children.Frontiers in allergy · 2024Article
- Child Maltreatment and Metabolic Syndrome: A Systematic Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Racial differences in associations between adverse childhood experiences and physical, mental, and behavioral health.SSM - population health · 2023Article
- Violent Victimization During Childhood in the United States: Associations With Revictimization and Health.Violence and victims · 2023Article
- Can adverse childhood experiences predict chronic health conditions? Development of trauma-informed, explainable machine learning models.Frontiers in public health · 2023Article
- Systems Medicine Approach for Tinnitus with Comorbid Disorders.Nutrients · 2022Article
- Child maltreatment, anxiety and depression, and asthma among British adults in the UK Biobank.The European respiratory journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse childhood experiences such as abuse and neglect are associated with subsequent immune dysregulation. Some studies show an association between adverse childhood experiences and asthma onset, although significant disparity in results exists in the published literature. We aimed to review available studies employing a prospective design that investigates associations between adverse childhood experience and asthma. A search protocol was developed and studies were drawn from four electronic journal databases. Studies were selected in accordance with pre-set inclusion criteria and relevant data were extracted. 12 studies, assessing data from a total of 31 524 individuals, were identified that investigate the impact of a range of adverse childhood experiences on the likelihood of developing asthma. Evidence suggests that chronic stress exposure and maternal distress in pregnancy operate synergistically with known triggers such as traffic-related air pollution to increase asthma risk. Chronic stress in early life is associated with an increased risk of asthma onset. There is evidence that adverse childhood experience increases the impact of traffic-related air pollution and inconsistent evidence that adverse childhood experience has an independent effect on asthma onset.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.