ReviewTrends in microbiology2015
The potential impact of coinfection on antimicrobial chemotherapy and drug resistance.
Review in Trends in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Prevalence and Patterns of Enteric Co-Infections Among Individuals Presenting with Cholera-like Diarrheal Disease During Seasonal Cholera Outbreaks.Pathogens (Basel, Switzerland) · 2025Article
- Coinfection affects the phenotypic but not genetic resistance of cattle to common parasites.Genetics, selection, evolution : GSE · 2025Article
- Prevalence ofMicroorganisms · 2024Article
- coiaf: Directly estimating complexity of infection with allele frequencies.PLoS computational biology · 2023Article
- Integration of immunoinformatics and cheminformatics to design and evaluate a multitope vaccine againstFrontiers in molecular biosciences · 2023Article
- Malaria and leishmaniasis: Updates on co-infection.Frontiers in immunology · 2023Review
- Protozoan co-infections and parasite influence on the efficacy of vaccines against bacterial and viral pathogens.Frontiers in microbiology · 2022Review
- Opportunist Coinfections by Nontuberculous Mycobacteria and Fungi in Immunocompromised Patients.Antibiotics (Basel, Switzerland) · 2020Review
- Bacterial co-infections with SARS-CoV-2.IUBMB life · 2020Review
- Topological data analysis to model the shape of immune responses during co-infections.Communications in nonlinear science & numerical simulation · 2020Article
- Effect of drug dose and timing of treatment on the emergence of drug resistanceEvolution, medicine, and public health · 2020Article
- Article
- Self-medication of antibiotics: investigating practice among university students at the Malaysian National Defence University.Infection and drug resistance · 2019Article
- Viral coinfection is shaped by host ecology and virus-virus interactions across diverse microbial taxa and environments.Virus evolution · 2017Article
- Where Sepsis and Antimicrobial Resistance Countermeasures Converge.Frontiers in public health · 2017Article
- Clinical potential of engineered cationic antimicrobial peptides against drug resistant biofilms.Expert review of anti-infective therapy · 2016Article
- Compromised Defenses: Exploitation of Epithelial Responses During Viral-Bacterial Co-Infection of the Respiratory Tract.PLoS pathogens · 2016Review
- Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens.Antimicrobial agents and chemotherapy · 2016Article
- Within-host competition and drug resistance in the human malaria parasite Plasmodium falciparum.Proceedings. Biological sciences · 2016Article
- Article
Corrections and comments
- Erratum issued
- Erratum issuedMina, Michael [Corrected to Mina, Michael J]
Authors and funding
9 authors.
Funding
Abstract
Across a range of pathogens, resistance to chemotherapy is a growing problem in both public health and animal health. Despite the ubiquity of coinfection, and its potential effects on within-host biology, the role played by coinfecting pathogens on the evolution of resistance and efficacy of antimicrobial chemotherapy is rarely considered. In this review, we provide an overview of the mechanisms of interaction of coinfecting pathogens, ranging from immune modulation and resource modulation, to drug interactions. We discuss their potential implications for the evolution of resistance, providing evidence in the rare cases where it is available. Overall, our review indicates that the impact of coinfection has the potential to be considerable, suggesting that this should be taken into account when designing antimicrobial drug treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.