ArticleOphthalmology2015
Influence of Fluorescein Angiography on the Diagnosis and Management of Retinopathy of Prematurity.
Article in Ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06044181 (Long Term Management of Peripheral Avascular Retina in Retinopathy of Prematurity Evaluated by Fundus Fluorescein Angiography.), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long Term Management of Peripheral Avascular Retina in Retinopathy of Prematurity Evaluated by Fundus Fluorescein Angiography.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- New insights in diagnosis and treatment for Retinopathy of Prematurity.International ophthalmology · 2016Pooled it
- Ranibizumab in retinopathy of prematurity - one-year follow-up of ophthalmic outcomes and two-year follow-up of neurodevelopmental outcomes from the CARE-ROP study.Acta ophthalmologica · 2022Trial
- Analysis of Discrepancy Between Diagnostic Clinical Examination Findings and Corresponding Evaluation of Digital Images in the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity Study.JAMA ophthalmology · 2016Trial
- Retinopathy of prematurity screening and treatment practice patterns: an African multi-country survey.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- WAVY OBLONG RETROGRADE MOVING SEGMENTS (WORMS) INTRAVENOUS FLUORESCEIN ANGIOGRAPHIC FINDING IN A NEONATE WITH RETINOPATHY OF PREMATURITY.Retinal cases & brief reports · 2026Article
- Persistent avascular retina in retinopathy of prematurity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Review
- Predictive Role of Fluorescein Angiography in Retinopathy of Prematurity.Pediatric reports · 2024Article
- Vascular imaging findings in retinopathy of prematurity.Acta ophthalmologica · 2024Review
- Occult retinal neovascularization following intravitreal bevacizumab and laser treatment for retinopathy of prematurity.BMC pediatrics · 2024Article
- A pilot optical coherence tomography angiography classification of retinal neovascularization in retinopathy of prematurity.Scientific reports · 2024Article
- Persistent Vascular Anomalies in Retinopathy of Prematurity Children: Ultrawide-field Fluorescein Angiography Findings until School Age.Ophthalmology science · 2023Article
- The retinal vascular growth rate in babies with retinopathy of prematurity could indicate treatment need.Indian journal of ophthalmology · 2022Article
- Angiographic findings in cases with a history of severe retinopathy of prematurity treated with anti-VEGFs: Follow-up to age 6 years.International ophthalmology · 2022Article
- Advantages of Widefield Optical Coherence Tomography in the Diagnosis of Retinopathy of Prematurity.Frontiers in pediatrics · 2021Article
- ULTRA-WIDE-FIELD IMAGING AND INTRAVENOUS FUNDUS FLUORESCEIN ANGIOGRAPHY IN INFANTS WITH RETINOPATHY OF PREMATURITY.Retina (Philadelphia, Pa.) · 2020Article
- Evaluation of Potential Systemic Adverse Events Related to Fluorescein Angiography in Pediatric Patients.Ophthalmology. Retina · 2020Article
- Inflammation-associated gene polymorphisms and clinical variables in the incidence and progression of retinopathy of prematurity.Central-European journal of immunology · 2020Article
- Assessment of vascular leakage and its development with FFA among patients treated with intravitreal anti-VEGF due to aggressive posterior ROP.International ophthalmology · 2019Article
- Describing Retinopathy of Prematurity: Current Limitations and New Challenges.Ophthalmology · 2019Article
- Fluorescein Angiographic Findings of Peripheral Retinal Vasculature after Intravitreal Conbercept versus Ranibizumab for Retinopathy of Prematurity.Journal of ophthalmology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo examine the influence of fluorescein angiography (FA) on the diagnosis and management of retinopathy of prematurity (ROP).
designProspective cohort study.
participantsNine recognized ROP experts (3 pediatric ophthalmologists and 6 retina specialists) interpreted 32 sets (16 color fundus photographs and 16 color fundus photographs paired with the corresponding FA images) of wide-angle retinal images from infants with ROP.
methodsAll experts independently reviewed the 32 image sets on a secure website and provided a diagnosis and management plan for the case presented, first based on color fundus photographs alone, and then based on color fundus photographs and corresponding FA images.
main outcome measuresSensitivity and specificity of the ROP diagnosis (zone, stage, plus disease, and category, i.e., no ROP, mild ROP, type 2 ROP, and ROP requiring treatment) were calculated using a consensus reference standard diagnosis, determined from the diagnosis of the color fundus photographs by 3 experienced readers in combination with the clinical diagnosis based on ophthalmoscopic examination. The κ statistic was used to analyze the average intergrader agreement among experts for the diagnosis of zone, stage, plus disease, and category.
resultsAddition of FA to color fundus photography resulted in a significant improvement in sensitivity for diagnosis of stage 3 or worse disease (39.8% vs. 74.1%; P = 0.008), type 2 or worse ROP (69.4% vs. 86.8%; P = 0.013), and pre-plus or worse disease (50.5 vs. 62.6%; P = 0.031). There was a nonsignificant trend toward improved sensitivity for diagnosis of ROP requiring treatment (22.2% vs. 40.3%; P = 0.063). Using the κ statistic, addition of FA to color fundus photography significantly improved intergrader agreement for diagnosis of ROP requiring treatment. Addition of FA to color fundus photography did not affect intergrader agreement significantly for the diagnosis of stage, zone, or plus disease.
conclusionsCompared with color fundus photography alone, FA may improve the sensitivity of diagnosis of ROP by experts, particularly for stage 3 disease. In addition, intergrader agreement for diagnosis of ROP requiring treatment may improve with FA interpretation.
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