ReviewCurrent hypertension reviews2015
Genomics and Pharmacogenomics of Salt-sensitive Hypertension.
Review in Current hypertension reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Trial
- Sodium, potassium, and blood pressure regulation in Latin American populations: a critical narrative review of multifactorial determinants.Frontiers in cardiovascular medicine · 2026Review
- Genetic Risk for Hypertension Increases the Effect of Salt Intake on the Risk of Incident CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- The impact of dietary salt on the development of hypertension and gut microbiome dysbiosis in captive-bred vervet monkeys (Chlorocebus aethiops).BMC veterinary research · 2025Article
- Oxidative Stress in Kidney Injury and Hypertension.Antioxidants (Basel, Switzerland) · 2024Review
- Article
- Sodium-Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt-Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling.Journal of the American Heart Association · 2022Article
- Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Comprehensive Assessment of Indian Variations in the Druggable Kinome Landscape Highlights Distinct Insights at the Sequence, Structure and Pharmacogenomic Stratum.Frontiers in pharmacology · 2022Article
- Role of Rho in Salt-Sensitive Hypertension.International journal of molecular sciences · 2021Review
- Peripheral Dopamine 2-Receptor Antagonist Reverses Hypertension in a Chronic Intermittent Hypoxia Rat Model.International journal of molecular sciences · 2020Article
- Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study.International journal of hypertension · 2020Article
- Genetic polymorphisms associated with reactive oxygen species and blood pressure regulation.The pharmacogenomics journal · 2019Review
- Increased arterial pressure in mice with overexpression of the ADHD candidate gene calcyon in forebrain.PloS one · 2019Article
- Identifying genetic markers associated with susceptibility to cardiovascular diseases.Future science OA · 2019Review
- Daily sodium intake influences the relationship between angiotensin-converting enzyme gene insertion/deletion polymorphism and hypertension in older adults.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Excessive dietary sodium intake and elevated blood pressure: a review of current prevention and management strategies and the emerging role of pharmaconutrigenetics.BMJ nutrition, prevention & health · 2018Review
- Do You Want to Ditch Sodium? Meet Nitric Oxide Synthase 1β at the Macula Densa.Journal of the American Society of Nephrology : JASN · 2016Article
- Gastrorenal Axis.Hypertension (Dallas, Tex. : 1979) · 2016Review
- Genetics of resistant hypertension: a novel pharmacogenomics phenotype.Current hypertension reports · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Salt sensitivity is estimated to be present in 51% of the hypertensive and 26% of the normotensive populations. The individual blood pressure response to salt is heterogeneous and possibly related to inherited susceptibility. Although the mechanisms underlying salt sensitivity are complex and not well understood, genetics can help to determine the blood response to salt intake. So far only a few genes have been found to be associated with salt-sensitive hypertension using candidate gene association studies. The kidney is critical to overall fluid and electrolyte balance and long-term regulation of blood pressure. Thus, the pathogenesis of salt sensitivity must involve a derangement in renal NaCl handling: an inability to decrease renal sodium transport and increase sodium excretion in the face of an increase in NaCl load that could be caused by aberrant counter-regulatory natriuretic/antinatriuretic pathways. We review here the literature regarding the gene variants associated with salt-sensitive hypertension and how the presence of these gene variants influences the response to antihypertensive therapy.
Indexed as
Identifiers
26028245W2460480860What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.