Evidence map›Paper›PMID 26028155›Full record

ArticleJournal of the International AIDS Society2015

Estimated age and gender profile of individuals missed by a home-based HIV testing and counselling campaign in a Botswana community.

Vlad Novitsky, Hermann Bussmann, Lillian Okui, Andrew Logan, Sikhulile Moyo, Erik van Widenfelt, Mompati Mmalane, Quanhong Lei, Molly P Holme, Joseph Makhema and 3 more

Abstract read
In one paragraph

Article in Journal of the International AIDS Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  15. High HIV-1 RNA Among Newly Diagnosed People in Botswana.AIDS research and human retroviruses · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Vlad NovitskyDepartment of Immunology and Infectious Diseases, Harvard School of Public Health Boston, MA, USA.
Hermann BussmannBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Lillian OkuiBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Andrew LoganBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Sikhulile MoyoBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Erik van WidenfeltBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Mompati MmalaneBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Quanhong LeiDepartment of Immunology and Infectious Diseases, Harvard School of Public Health Boston, MA, USA.
Molly P HolmeDepartment of Immunology and Infectious Diseases, Harvard School of Public Health Boston, MA, USA.
Joseph MakhemaDepartment of Immunology and Infectious Diseases, Harvard School of Public Health Boston, MA, USA.
Shahin LockmanDepartment of Immunology and Infectious Diseases, Harvard School of Public Health Boston, MA, USA.
Victor DegruttolaDepartment of Immunology and Infectious Diseases, Harvard School of Public Health Boston, MA, USA.
M EssexDepartment of Immunology and Infectious Diseases, Harvard School of Public Health Boston, MA, USA.

Funding

INTERNATIONAL TRAINING IN AIDS-RELATED EPIDEMIOLOGYD43TW000004 · FIC · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ESSEX, MYRON E · 1988 to 2012
$13.4M
An HIV Prevention Program for Mochudi, BotswanaR01AI083036 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI ESSEX, MYRON E · 2009 to 2012
$3.5M
FIC NIH HHS D43 TW000004NIAID NIH HHS R01 AI083036
6 · The paper itself

Abstract

introductionIt would be useful to understand which populations are not reached by home-based HIV-1 testing and counselling (HTC) to improve strategies aimed at linking these individuals to care and reducing rates of onward HIV transmission.

methodsWe present the results of a baseline home-based HTC (HBHTC) campaign aimed at counselling and testing residents aged 16 to 64 for HIV in the north-eastern sector of Mochudi, a community in Botswana with about 44,000 inhabitants. Collected data were compared with population references for Botswana, the United Nations (UN) estimates based on the National Census data and the Botswana AIDS Impact Survey IV (BAIS-IV). Analyzed data and references were stratified by age and gender.

resultsA total of 6238 age-eligible residents were tested for HIV-1; 1247 (20.0%; 95% CI 19.0 to 21.0%) were found to be HIV positive (23.7% of women vs. 13.4% of men). HIV-1 prevalence peaked at 44% in 35- to 39-year-old women and 32% in 40- to 44-year-old men. A lower HIV prevalence rate, 10.9% (95% CI 9.5 to 12.5%), was found among individuals tested for the first time. A significant gender gap was evident in all analyzed subsets. The existing HIV transmission network was analyzed by combining phylogenetic mapping and household structure. Between 62.4 and 71.8% of all HIV-positive individuals had detectable virus. When compared with the UN and BAIS-IV estimates, the proportion of men missed by the testing campaign (48.5%; 95% CI 47.0 to 50.0%) was significantly higher than the proportion of missed women (14.2%; 95% CI 13.2 to 15.3%; p<0.0001). The estimated proportion of missed men peaked at about 60% in the age group 30 to 39 years old. The proportions of missed women were substantially smaller, at approximately 28% within the age groups 30 to 34 and 45 to 49 years old.

conclusionsThe HBHTC campaign seems to be an efficient tool for reaching individuals who have never been tested previously in southern African communities. However, about half of men from 16 to 64 years old were not reached by the HBHTC, including about 60% of men between 30 and 40 years old. Alternative HTC strategies should be developed to bring these men to care, which will contribute to reduction of HIV incidence in communities.

Indexed as

CounselingHIV-1AdolescentAdultAge FactorsBotswanaFemaleHIV InfectionsHumansIncidenceMaleMiddle AgedResidence CharacteristicsageBotswanagenderHIV-1home-based HTCindividuals tested for the first timemissing individuals

Identifiers

PMID26028155
PMCPMC4450241

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.