ArticleNature communications2015
Coordination and fine motor control depend on Drosophila TRPγ.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Proprioceptive limit detectors contribute to sensorimotor control of the Drosophila leg.Nature communications · 2026Article
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- Article
- Expression profiles analysis and roles in immunity of transient receptor potential (TRP) channel genes in Spodoptera frugiperda.BMC genomics · 2025Article
- Cholesterol taste avoidance ineLife · 2025Article
- TRPγ regulates lipid metabolism througheLife · 2025Article
- Evolution of chemosensory tissues and cells across ecologically diverse Drosophilids.Nature communications · 2024Article
- Mechanosensory Control of Locomotion in Animals and Robots: Moving Forward.Integrative and comparative biology · 2023Review
- The Voltage-Gated Sodium Channel ineNeuro · 2023Article
- Parallelized computational 3D video microscopy of freely moving organisms at multiple gigapixels per second.Nature photonics · 2023Article
- Adaptive behaviors of Drosophila larvae on slippery surfaces.Journal of biological physics · 2023Article
- Markers and mechanisms of death inFrontiers in aging · 2023Article
- Mutations in trpγ, the homologue of TRPC6 autism candidate gene, causes autism-like behavioral deficits in Drosophila.Molecular psychiatry · 2022Article
- Identification of an arthropod molecular target for plant-derived natural repellents.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Article
- Food supplementation with wheat gluten leads to climbing performance decline inmicroPublication biology · 2022Article
- Phase response analyses support a relaxation oscillator model of locomotor rhythm generation ineLife · 2021Article
- Drosophila females receive male substrate-borne signals through specific leg neurons during courtship.Current biology : CB · 2021Article
- Proprioception, the regulator of motor function.BMB reports · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Motor coordination is broadly divided into gross and fine motor control, both of which depend on proprioceptive organs. However, the channels that function specifically in fine motor control are unknown. Here we show that mutations in trpγ disrupt fine motor control while leaving gross motor proficiency intact. The mutants are unable to coordinate precise leg movements during walking, and are ineffective in traversing large gaps due to an inability in making subtle postural adaptations that are requisite for this task. TRPγ is expressed in proprioceptive organs, and is required in both neurons and glia for gap crossing. We expressed TRPγ in vitro, and found that its activity is promoted by membrane stretch. A mutation eliminating the Na(+)/Ca(2+) exchanger suppresses the gap-crossing phenotype of trpγ flies. Our findings indicate that TRPγ contributes to fine motor control through mechanical activation in proprioceptive organs, thereby promoting Ca(2+) influx, which is required for function.
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Registered trials
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