SynthesisBMC cancer2015
Lymph node density as a prognostic variable in node-positive bladder cancer: a meta-analysis.
Synthesis in BMC cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Which lymph node dissection template is optimal for radical cystectomy? A systematic review and Bayesian network meta-analysis.Frontiers in oncology · 2022Pooled it
- Prognostic value of lymph node ratio in laryngeal and hypopharyngeal squamous cell carcinoma: a systematic review and meta-analysis.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2020Pooled it
- Radical cystectomy for bladder cancer in Sub-Saharan Africa: techniques, challenges, and survival outcomes: a comprehensive review.BMC surgery · 2025Review
- Progress of fluorescence imaging in lymph node dissection surgery for prostate and bladder cancer.Frontiers in oncology · 2024Review
- A predictive model for patients with local-regionally advanced oropharyngeal squamous cell carcinoma treated after cervical lymph node dissection.Journal of cancer research and clinical oncology · 2023Article
- Predictive models of long-term survival outcomes following radical cystectomy.Cancer medicine · 2023Article
- Degenerative Changes in Aging Human Pelvic Lymph Nodes-A Reason to Rethink Staging and Therapy of Regional Malignancies?Cancers · 2023Article
- Review
- Development of scalable lymphatic system in the 4D XCAT phantom: Application to quantitative evaluation of lymphoma PET segmentations.Medical physics · 2022Article
- A Prognostic Nomogram Based on Log Odds of Positive Lymph Nodes to Predict Overall Survival for Non-Metastatic Bladder Cancer Patients after Radical Cystectomy.Current oncology (Toronto, Ont.) · 2022Article
- Impact of preoperative chemotherapy on pathologic nodal status in muscle-invasive bladder cancer: optimal lymphadenectomy in the preoperative chemotherapy era.Journal of cancer research and clinical oncology · 2022Article
- Nomograms to predict individual prognosis of patients with primary signet ring cell carcinoma of the urinary bladder.Translational cancer research · 2021Article
- The Adequacy of Pelvic Lymphadenectomy During Radical Cystectomy for Carcinoma Urinary Bladder: A Narrative Review of Literature.Frontiers in surgery · 2021Review
- The evolving role of lymphadenectomy for bladder cancer: why, when, and how.Translational andrology and urology · 2020Review
- Radical cystectomy: a review of techniques, developments and controversies.Translational andrology and urology · 2020Review
- Evaluation of lymph node ratio and lymph node yield as prognosticators of locoregional recurrence in p16-associated oropharyngeal squamous cell carcinoma.Head & neck · 2020Article
- Microlocalization and clinical significance of stabilin-1World journal of urology · 2020Article
- Pelvic Lymph Node Dissection During Cystectomy for Patients With Bladder Carcinoma With Variant Histology: Does Histologic Type Matter?Frontiers in oncology · 2020Article
- How many lymph nodes are enough? Assessing the adequacy of lymph node yield for staging in favorable histology wilms tumor.Journal of pediatric surgery · 2019Article
- Pelvic lymph node dissection during radical cystectomy for muscle-invasive bladder cancer.Nature reviews. Urology · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough lymph node (LN) status and the LN burden determine the outcome of bladder cancer patients treated with cystectomy, compelling arguments have been made for the incorporation of LN density into the current staging system. Here, we investigate the relationship between LN density and clinical outcome in patients with LN-positive disease, following radical cystectomy for bladder cancer.
methodsPubMed, SCOPUS, the Institute for Scientific Information Web of Science, and the Cochrane Library were searched to identify relevant published literature.
resultsFourteen studies were included in the meta-analysis, with a total number of 3311 patients. Of these 14 publications, 6 studies, (533 patients), 10 studies (2966 patients), and 5 studies (1108 patients) investigated the prognostic association of LN density with disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS), respectively. The pooled hazard ratio (HR) for DFS was 1.45 (95% confidence interval [CI], 1.10-1.91) without heterogeneity (I2=0%, p=0.52). Higher LN density was significantly associated with poor DSS (pooled HR, 1.53; 95% CI, 1.23-1.89). However, significant heterogeneity was found between studies (I2=66%, p=0.002). The pooled HR for OS was statistically significant (pooled HR, 1.45; 95% CI, 1.11-1.90) without heterogeneity (I2=42%, p=0.14). The results of the Begg and Egger tests suggested that publication bias was not evident in this meta-analysis.
conclusionsThe data from this meta-analysis indicate that LN density is an independent predictor of clinical outcome in LN-positive patients. LN density may be useful in future staging systems, thus allowing better prognostic classification of LN-positive bladder cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.