ArticleCell2015
A Corticostriatal Path Targeting Striosomes Controls Decision-Making under Conflict.
Article in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 185 papers, 1 of them a synthesis that pooled it.
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Who cites it
185 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gray matter abnormalities in patients with major depressive disorder and social anxiety disorder: a voxel-based meta-analysis.Brain imaging and behavior · 2023Pooled it
- Dissecting the Function of Hippocampal Oscillations in a Human Anxiety Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Trial
- Neural basis of compositional control.Nature · 2026Article
- Top-down corticostriatal control of adaptive restraint during motivational conflict.Science advances · 2026Article
- Noninvasive Mapping of Striosome-Matrix Imbalance in Early Psychosis.Biological psychiatry global open science · 2026Article
- High-fat diet exposure, internal state, and reward value influence decision making during motivational conflict.Neurobiology of stress · 2026Article
- Acquisition-Recruited and MOR-Expressing Striatal dMSNs Differentially Regulate Extinction and Cue-Induced Relapse of Alcohol Seeking.Addiction biology · 2026Article
- Common and Distinct Neural Substrates for Approach- and Avoidance-Motivated Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A diffusion MRI-based structural assessment of the striatal compartments, striosome and matrix, in Obsessive Compulsive Disorder.Research square · 2026Article
- Role of the inferior frontal gyrus and impulsivity in approach motivation: A low-frequency repetitive transcranial magnetic stimulation study.Cognitive, affective & behavioral neuroscience · 2026Article
- A Selective Cortico-Limbic Network Organizes Behavior During Reward Seeking Under Threat.Journal of neuroscience research · 2026Article
- Major urinary protein 1 modulates neuronal excitability in the medial prefrontal cortex in a male mouse model of affective empathy.Nature communications · 2026Article
- Prediction error correlates in the striosome-dopamine circuit emerge from information gain.Nature communications · 2026Article
- Striosomal ghrelin receptor activity controls reward-cost integration.Research square · 2026Article
- Diazepam selectively biases approach during threat-reward conflict while sparing reactive avoidance.Psychopharmacology · 2026Article
- Dual-engram architecture within a single striatal cell type distinctly controls alcohol relapse and extinction.Neuron · 2026Article
- Targeting dopamine transporter for treating social transmission of depression-like behaviors in male mice.Nature communications · 2026Article
- Npas4 regulates synaptic development in the patch/striosome compartment and early affective vocalization in neonatal mice.Molecular brain · 2026Article
- A corticostriatal circuit mediates the switching of defensive responses to an approaching threat.Translational psychiatry · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
125 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
A striking neurochemical form of compartmentalization has been found in the striatum of humans and other species, dividing it into striosomes and matrix. The function of this organization has been unclear, but the anatomical connections of striosomes indicate their relation to emotion-related brain regions, including the medial prefrontal cortex. We capitalized on this fact by combining pathway-specific optogenetics and electrophysiology in behaving rats to search for selective functions of striosomes. We demonstrate that a medial prefronto-striosomal circuit is selectively active in and causally necessary for cost-benefit decision-making under approach-avoidance conflict conditions known to evoke anxiety in humans. We show that this circuit has unique dynamic properties likely reflecting striatal interneuron function. These findings demonstrate that cognitive and emotion-related functions are, like sensory-motor processing, subject to encoding within compartmentally organized representations in the forebrain and suggest that striosome-targeting corticostriatal circuits can underlie neural processing of decisions fundamental for survival.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.