Evidence map›Paper›PMID 26026817›Full record

ArticleWorld journal of urology2016

Extent of pelvic lymph node dissection in penile cancer may impact survival.

Kamran Zargar-Shoshtari, Pranav Sharma, Rosa Djajadiningrat, Mario Catanzaro, Ding-Wei Ye, Yao Zhu, Nicola Nicolai, Simon Horenblas, Philippe E Spiess

Abstract readComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in World journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Immune-based therapies in penile cancer.Nature reviews. Urology · 2022
    Review
  4. Review
  5. Article
  6. Article
  7. Penile cancer: a Brazilian consensus statement for low- and middle-income countries.Journal of cancer research and clinical oncology · 2020
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Kamran Zargar-ShoshtariDepartment of Genitourinary Oncology, Moffitt Cancer Center, 12902 Magnolia Drive Office 12538, Tampa, FL, 33612, USA.
Pranav SharmaDepartment of Genitourinary Oncology, Moffitt Cancer Center, 12902 Magnolia Drive Office 12538, Tampa, FL, 33612, USA.
Rosa DjajadiningratDepartment of Urology, Netherlands Cancer Institute- Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Mario CatanzaroDepartment of Urology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Ding-Wei YeFudan University Shanghai Cancer Center, Department of Urology, Shanghai, China.
Yao ZhuFudan University Shanghai Cancer Center, Department of Urology, Shanghai, China.
Nicola NicolaiDepartment of Urology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Simon HorenblasDepartment of Urology, Netherlands Cancer Institute- Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Philippe E SpiessDepartment of Genitourinary Oncology, Moffitt Cancer Center, 12902 Magnolia Drive Office 12538, Tampa, FL, 33612, USA. philippe.spiess@moffitt.org.
Fondazione IRCCS Istituto Nazionale dei Tumori · ITFudan University Shanghai Cancer Center · CNMoffitt Cancer Center · USThe Netherlands Cancer Institute · NLUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCurrent guidelines on management of penile carcinoma (PC) recommend ipsilateral pelvic lymph node dissection (PLND) in patients with inguinal lymph node metastasis (LNM) who meet specific criteria. The aim of this article was to assess outcomes in patients treated with bilateral PLND in the presence of unilateral metastatic pelvic nodes.

methodsAfter IRB approval, four international centers contributed to this study. Men with PC and unilateral inguinal LNM and pelvic node metastases were retrospectively analyzed. Estimates of overall survival (OS) and cancer-specific survival were provided by the Kaplan-Meier method. Comparisons between subgroups were made using the log-rank test, and Cox regression analysis was used to adjust comparisons for covariates of interest.

resultsFrom 1978 to 2012, fifty-one men with unilateral inguinal LNM and positive pelvic nodes on PLND were identified. Thirty-eight (75 %) had ipsilateral and 13 (25 %) had bilateral PLND. Except the extent of the PLND, patients were comparable with respect to disease and therapeutic interventions. The Kaplan-Meier estimated median OS was significantly longer in the bilateral PLND patients (21.7 vs. 13.1, p = 0.051). On Cox regression analysis, bilateral PLND [HR 0.25, (95 % CI 0.10-0.64)], multiple pelvic node involvement [HR 2.12 (95 % CI 1.02-4.43)], neoadjuvant chemotherapy [HR 0.01, (95 % CI 0.02-0.44)] and adjuvant therapies [HR 0.16, (95 % CI 0.06-0.45)] (compared to no additional therapy) were independent predictors of OS.

conclusionsMen with PC and pelvic node metastases may benefit from a bilateral PLND. This hypothesis requires further confirmation.

Indexed as

AdultAgedAged, 80 and overCarcinoma, Squamous CellChinaFollow-Up StudiesHumansLymphatic MetastasisLymph Node ExcisionLymph NodesMaleMiddle AgedNetherlandsPelvisPenile NeoplasmsRetrospective StudiesAlgorithmsLymph node excisionPenile neoplasms

Identifiers

PMID26026817
OpenAlexW2103853341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.