Evidence map›Paper›PMID 26026737›Full record

Trial reportGynecologic oncology2015

Physical activity and sedentary behavior in breast cancer survivors: New insight into activity patterns and potential intervention targets.

Siobhan M Phillips, Kevin W Dodd, Jeremy Steeves, James McClain, Catherine M Alfano, Edward McAuley

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Gynecologic oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03760653 (Physical Activity Along With a Probiotic for the Immune System and Quality of Life Improvement in Breast Cancer Survivor), which is not on this map. Cited by 65 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03760653 nawithdrawnnot on this mapstarted 2018, after this paper: background citation

Physical Activity Along With a Probiotic for the Immune System and Quality of Life Improvement in Breast Cancer Survivor: A Randomised Controlled Pilot Study

TypeinterventionalSponsorUniversidad Europea de MadridRan2018 to 2019Enrolled0ConditionsBreast Cancer FemalesArmsPhysical Exercise and probiotic group, Probiotic group, Placebo group
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Feasibility of a comprehensive supervised exercise program during and after treatment of head and neck cancer: a mixed-methods study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
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  7. Moderators of physical activity and quality of life response to a physical activity intervention for breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Trial
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  10. Ease of walking associates with greater free-living physical activity and reduced depressive symptomology in breast cancer survivors: pilot randomized trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Trial
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  15. Observational
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Siobhan M PhillipsDepartment of Preventive Medicine, Northwestern University, United States. Electronic address: smphillips@northwestern.edu.
Kevin W DoddDivision of Cancer Prevention, National Cancer Institute, United States.
Jeremy SteevesDepartment of Kinesiology, University of Wisconsin-Milwaukee, United States.
James McClainDivision of Cancer Control and Population Science, National Cancer Institute, United States.
Catherine M AlfanoDivision of Cancer Control and Population Science, National Cancer Institute, United States.
Edward McAuleyDepartment of Kinesiology and Community Health, University of Illinois Urbana-Champaign, United States.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
Activity Gait and Efficacy (AGE) in Order WomenR01AG020118 · NIA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI MCAULEY, EDWARD · 2002 to 2013
$2.7M
Activity, Gait, and Efficacy (AGE II): Functional Limtations and Quality of LifeR56AG020118 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MCAULEY, EDWARD · 2009 to 2009
$498k
Determinants and Correlates of Physical Activity in Breast Cancer SurvivorsF31AG034025 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI PHILLIPS, SIOBHAN MARIE · 2009 to 2010
$71k
Intramural NIH HHS Z99 CA999999NCI NIH HHS P30 CA060553NIA NIH HHS AG020118NIA NIH HHS F31 AG034025NIA NIH HHS F31AG034025NIA NIH HHS R01 AG020118NIA NIH HHS R56 AG020118
6 · The paper itself

Abstract

backgroundInactivity and sedentary behavior are related to poorer health outcomes in breast cancer survivors. However, few studies examining these behaviors in survivors have used objective measures, considered activities other than moderate-to-vigorous intensity activity (MVPA) and/or sedentary behavior (i.e. low intensity activities) or compared survivors to healthy controls. The purpose of the present study is to compare accelerometer-measured activity of various intensities (total, light, lifestyle, MVPA) and sedentary behavior between breast cancer survivors and non-cancer controls.

methodsAn imputation-based approach of independent sample t-tests adjusting for multiple comparisons was used to compare estimates of participation in each activity and sedentary behavior between survivors [n=398; M(SD)age=56.95 (9.11)] and block-matched non-cancer controls [n=1120; M(SD)age=54.88 (16.11)]. Potential moderating effects of body mass index (BMI), age, and education were also examined.

resultsBreast cancer survivors registered less daily total (282.8 v. 346.9) light (199.1 v. 259.3) and lifestyle (62.0 v. 71.7) activity minutes and more MVPA (21.6 v. 15.9) and sedentary behavior (555.7 v. 500.6) minutes than controls (p<0.001 for all). These relationships were largely consistent across BMI, age and education. On average, survivors spent an estimated 66.4% of their waking time sedentary and 31.1% in light/lifestyle activity and 2.6% in MVPA.

conclusionsBreast cancer survivors are more sedentary and participate in less low intensity activity than controls. Although survivors registered more MVPA, these levels were insufficient. Future research should explore these differences and potential benefits of targeting low intensity activities and reducing sedentary time in this population.

Indexed as

Sedentary BehaviorAccelerometryAdultBreast NeoplasmsCase-Control StudiesFemaleHumansMiddle AgedMonitoring, PhysiologicMotor ActivityNeoplasm StagingPrognosisSurvivorsBreast cancer survivorsExercisePhysical activitySedentary behavior

Identifiers

PMID26026737
PMCPMC4755516

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.