ArticleMedical science monitor : international medical journal of experimental and clinical research2015
IKBKE Upregulation is Positively Associated with Squamous Cell Carcinoma of the Lung In Vivo and Malignant Transformation of Human Bronchial Epithelial Cells In Vitro.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- IKBKE modulates autophagy and progestin resistance in endometrial cancer.Frontiers in oncology · 2025Article
- Strategies for understanding the role of cellular heterogeneity in the pathogenesis of lung cancer: a cell model for chronic exposure to cigarette smoke extract.BMC pulmonary medicine · 2022Article
- Article
- Silencing IKBKE inhibits the migration and invasion of glioblastoma by promoting Snail1 degradation.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022Article
- Role of IKKε in the Metabolic Diseases: Physiology, Pathophysiology, and Pharmacology.Frontiers in pharmacology · 2022Review
- CYT387, a potent IKBKE inhibitor, suppresses human glioblastoma progression by activating the Hippo pathway.Journal of translational medicine · 2021Article
- Advances in IKBKE as a potential target for cancer therapy.Cancer medicine · 2020Review
- MCCK1 enhances the anticancer effect of temozolomide in attenuating the invasion, migration and epithelial-mesenchymal transition of glioblastoma cells in vitro and in vivo.Cancer medicine · 2019Article
- Differential Characterization of Temozolomide-Resistant Human Glioma Cells.International journal of molecular sciences · 2018Article
- Extrinsic Calcitonin Gene-Related Peptide Inhibits Hyperoxia-Induced Alveolar Epithelial Type II Cells Apoptosis, Oxidative Stress, and Reactive Oxygen Species (ROS) Production by Enhancing Notch 1 and Homocysteine-Induced Endoplasmic Reticulum Protein (HERP) Expression.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- IKBKE regulates cell proliferation and epithelial-mesenchymal transition of human malignant glioma via the Hippo pathway.Oncotarget · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe IκB kinase inhibitor of κB kinase epsilon (IKBKE) is overexpressed in several human cancers. Although IKBKE plays an important role in smoking-induced non-small cell lung cancer carcinogenesis, its role in squamous cell carcinoma of the lung (SCCL) remains unclear. MATERIAL AND
methodsIKBKE protein expression was assessed by immunohistochemistry in 288 paraffinized SCCL specimens (with adjacent squamous dysplastic and normal tissue). IKBKE mRNA expression was assessed by reverse transcription PCR in 66 fresh SCCL specimens (with adjacent squamous dysplastic and normal tissue). Separately, immortalized human bronchial epithelial cells were cultured in 7 groups: untreated control, ethanol-treated, and cigarette smoke condensate (CSC)-exposed for 10, 20, 30, 40, and 50 generations (P10, P20, P30, P40, and P50, respectively). Malignant transformation was assessed by serum resistance and colony formation assays. IKBKE protein and mRNA expression were detected by Western blotting and reverse transcription PCR, respectively.
resultsIKBKE protein expression showed a significant upward trend from normal bronchial epithelium to squamous cell dysplasia to SCCL. IKBKE protein expression in SCCL was significantly associated with smoking status, smoking index, degree of differentiation, and clinical stage. Current and former smokers displayed significantly higher IKBKE protein and mRNA expression than non-smokers. IKBKE protein and mRNA expression displayed a significant upward trend with the smoking index. P30, P40, and P50 CSC-exposed cells displayed malignant transformation with increasing IKBKE mRNA and protein expression from P20 through P50.
conclusionsIKBKE upregulation is positively associated with SCCL and smoking indices as well as CSC-induced malignant transformation of human bronchial epithelial cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.