ArticleAge and ageing2015
Theory of mind impairment in patients with behavioural variant fronto-temporal dementia (bv-FTD) increases caregiver burden.
Article in Age and ageing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Empathy and Psychological Outcomes in Informal Caregivers of Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Pooled it
- Enhancing theory of mind in behavioural variant frontotemporal dementia with transcranial direct current stimulation.Cognitive, affective & behavioral neuroscience · 2018Trial
- Understanding barriers and optimizing socio-cognitive assessment in the diagnosis of neurocognitive disorders.Journal of neuropsychology · 2025Article
- Destination memory in behavioral-variant frontotemporal dementia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Caregiving in the face of empathy loss in Frontotemporal Dementia: an integrative review.Aging & mental health · 2025Review
- Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- So Many Are "Few," but so Few Are Also "Few" - Reduced Semantic Flexibility in bvFTD Patients.Frontiers in psychology · 2020Article
- Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach.Neuropsychiatric disease and treatment · 2019Review
- Transcranial direct current stimulation enhances theory of mind in Parkinson's disease patients with mild cognitive impairment: a randomized, double-blind, sham-controlled study.Translational neurodegeneration · 2019Article
- Social cognition in patients with intracranial tumors: do we forget something in the routine neuropsychological examination?Journal of neuro-oncology · 2018Article
- Cognitive and Affective Perspective-Taking: Evidence for Shared and Dissociable Anatomical Substrates.Frontiers in neurology · 2018Review
- Dementia Caregiver Burden: a Research Update and Critical Analysis.Current psychiatry reports · 2017Review
- Theory of Mind and Its Neuropsychological and Quality of Life Correlates in the Early Stages of Amyotrophic Lateral Sclerosis.Frontiers in psychology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundTheory of mind (ToM), the capacity to infer the intention, beliefs and emotional states of others, is frequently impaired in behavioural variant fronto-temporal dementia patients (bv-FTDp); however, its impact on caregiver burden is unexplored.
settingNational Institute of Neurological Disorders and Stroke, National Institutes of Health. SUBJECTS: bv-FTDp (n = 28), a subgroup of their caregivers (n = 20) and healthy controls (n = 32).
methodswe applied a faux-pas (FP) task as a ToM measure in bv-FTDp and healthy controls and the Zarit Burden Interview as a measure of burden in patients' caregivers. Patients underwent structural MRI; we used voxel-based morphometry to examine relationships between regional atrophy and ToM impairment and caregiver burden.
resultsFP task performance was impaired in bv-FTDp and negatively associated with caregiver burden. Atrophy was found in areas involved in ToM. Caregiver burden increased with greater atrophy in left lateral premotor cortex, a region associated in animal models with the presence of mirror neurons, possibly involved in empathy.
conclusionToM impairment in bv-FTDp is associated with increased caregiver burden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.