ArticleApplied and environmental microbiology2015
"Wigglesworthia morsitans" Folate (Vitamin B9) Biosynthesis Contributes to Tsetse Host Fitness.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 83 citations in OpenAlex.
- Bacterial Symbionts Associated with Wild Tsetse Flies (Diptera: Glossinidae) in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2026Review
- Genome assembly and protein structure modeling reveal key molecular features of divergentMicrobiology spectrum · 2026Article
- mir-31 mediated control of bacteriome size in tsetse flies.Current research in insect science · 2025Article
- Insect‒microbe symbiosis-based strategies offer a new avenue for the management of insect pests and their transmitted pathogens.Crop health · 2024Review
- Patterns of microbiome composition in tsetse flyMicrobiology spectrum · 2024Article
- The plant-sucking insect selects assembly of the gut microbiota from environment to enhance host reproduction.NPJ biofilms and microbiomes · 2024Article
- Draft genome sequence ofMicrobiology resource announcements · 2024Article
- Lipid metabolism dysfunction following symbiont elimination is linked to altered Kennedy pathway homeostasis.iScience · 2023Article
- Symbioses shape feeding niches and diversification across insects.Nature ecology & evolution · 2023Article
- Cuticle supplementation and nitrogen recycling by a dual bacterial symbiosis in a family of xylophagous beetles.The ISME journal · 2023Article
- The gut symbiont Sphingomonas mediates imidacloprid resistance in the important agricultural insect pest Aphis gossypii Glover.BMC biology · 2023Article
- Article
- Review
- Prevalence of Spiroplasma and interaction with wild Glossina tachinoides microbiota.Parasite (Paris, France) · 2023Article
- Symbiosis preservation: Putative regulation of fatty acyl-CoA reductase by miR-31a within the symbiont harboring bacteriome through tsetse evolution.Frontiers in microbiology · 2023Article
- The Tsetse Metabolic Gambit: Living on Blood by Relying on Symbionts Demands Synchronization.Frontiers in microbiology · 2022Review
- Insect-host control of obligate, intracellular symbiont density.Proceedings. Biological sciences · 2021Article
- Infection with endosymbiotic Spiroplasma disrupts tsetse (Glossina fuscipes fuscipes) metabolic and reproductive homeostasis.PLoS pathogens · 2021Article
- The holobiont transcriptome of teneral tsetse fly species of varying vector competence.BMC genomics · 2021Article
- Inhibition of a nutritional endosymbiont by glyphosate abolishes mutualistic benefit on cuticle synthesis in Oryzaephilus surinamensis.Communications biology · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Closely related ancient endosymbionts may retain minor genomic distinctions through evolutionary time, yet the biological relevance of these small pockets of unique loci remains unknown. The tsetse fly (Diptera: Glossinidae), the sole vector of lethal African trypanosomes (Trypanosoma spp.), maintains an ancient and obligate mutualism with species belonging to the gammaproteobacterium Wigglesworthia. Extensive concordant evolution with associated Wigglesworthia species has occurred through tsetse species radiation. Accordingly, the retention of unique symbiont loci between Wigglesworthia genomes may prove instrumental toward host species-specific biological traits. Genome distinctions between "Wigglesworthia morsitans" (harbored within Glossina morsitans bacteriomes) and the basal species Wigglesworthia glossinidia (harbored within Glossina brevipalpis bacteriomes) include the retention of chorismate and downstream folate (vitamin B9) biosynthesis capabilities, contributing to distinct symbiont metabolomes. Here, we demonstrate that these W. morsitans pathways remain functionally intact, with folate likely being systemically disseminated through a synchronously expressed tsetse folate transporter within bacteriomes. The folate produced by W. morsitans is demonstrated to be pivotal for G. morsitans sexual maturation and reproduction. Modest differences between ancient symbiont genomes may still play key roles in the evolution of their host species, particularly if loci are involved in shaping host physiology and ecology. Enhanced knowledge of the Wigglesworthia-tsetse mutualism may also provide novel and specific avenues for vector control.
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