ArticleApplied and environmental microbiology2015
SnPKS19 Encodes the Polyketide Synthase for Alternariol Mycotoxin Biosynthesis in the Wheat Pathogen Parastagonospora nodorum.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 36 citations in OpenAlex.
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- Biosynthetic potential of the culturable foliar fungi associated with field-grown lettuce.Applied microbiology and biotechnology · 2025Article
- Genome mining reveals the distribution of biosynthetic gene clusters in Alternaria and related fungal taxa within the family Pleosporaceae.BMC genomics · 2025Article
- The Velvet transcription factor PnVeA regulates necrotrophic effectors and secondary metabolism in the wheat pathogen Parastagonospora nodorum.BMC microbiology · 2024Article
- Antibacterial insights into alternariol and its derivative alternariol monomethyl ether produced by a marine fungus.Applied and environmental microbiology · 2024Article
- Heterologous Expression of Secondary Metabolite Genes inJournal of fungi (Basel, Switzerland) · 2022Article
- Roles of AaFrontiers in microbiology · 2022Article
- A Genomic and Transcriptomic Study on the DDT-ResistantMicroorganisms · 2021Article
- Multifarious Elicitors: Invoking Biosynthesis of Various Bioactive Secondary Metabolite in Fungi.Applied biochemistry and biotechnology · 2021Article
- Bioactive α-Pyrone Derivatives from the Endophytic FungusFrontiers in chemistry · 2021Article
- Genome mining of a fungal endophyte of Taxus yunnanensis (Chinese yew) leads to the discovery of a novel azaphilone polyketide, lijiquinone.Microbial biotechnology · 2020Article
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- Volatile Molecules Secreted by the Wheat PathogenFrontiers in microbiology · 2020Article
- Effects of Essential Oil Citral on the Growth, Mycotoxin Biosynthesis and Transcriptomic Profile ofToxins · 2019Article
- Chemical Diversity and Biological Activities ofJournal of fungi (Basel, Switzerland) · 2018Review
- Polyketide synthases of Diaporthe helianthi and involvement of DhPKS1 in virulence on sunflower.BMC genomics · 2018Article
- Review
- Dissecting the role of histidine kinase and HOG1 mitogen-activated protein kinase signalling in stress tolerance and pathogenicity of Parastagonospora nodorum on wheat.Microbiology (Reading, England) · 2016Article
- Article
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4 authors at 1 institution in 1 country.
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Abstract
Alternariol (AOH) is an important mycotoxin from the Alternaria fungi. AOH was detected for the first time in the wheat pathogen Parastagonospora nodorum in a recent study. Here, we exploited reverse genetics to demonstrate that SNOG_15829 (SnPKS19), a close homolog of Penicillium aethiopicum norlichexanthone (NLX) synthase gene gsfA, is required for AOH production. We further validate that SnPKS19 is solely responsible for AOH production by heterologous expression in Aspergillus nidulans. The expression profile of SnPKS19 based on previous P. nodorum microarray data correlated with the presence of AOH in vitro and its absence in planta. Subsequent characterization of the ΔSnPKS19 mutants showed that SnPKS19 and AOH are not involved in virulence and oxidative stress tolerance. Identification and characterization of the P. nodorum SnPKS19 cast light on a possible alternative AOH synthase gene in Alternaria alternata and allowed us to survey the distribution of AOH synthase genes in other fungal genomes. We further demonstrate that phylogenetic analysis could be used to differentiate between AOH synthases and the closely related NLX synthases. This study provides the basis for studying the genetic regulation of AOH production and for development of molecular diagnostic methods for detecting AOH-producing fungi in the future.
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