ArticleExperimental brain research2015
Motion sickness is associated with an increase in vestibular modulation of skin but not muscle sympathetic nerve activity.
Article in Experimental brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04976101 (A Pilot Study to Assess Sinusoidal Galvanic Vestibular Stimulation in Neurogenic Orthostatic Hypotension), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study to Assess Sinusoidal Galvanic Vestibular Stimulation in Neurogenic Orthostatic Hypotension
Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Cortical and subcortical correlates of perceptual responses during sinusoidal galvanic vestibular stimulation: a BOLD fMRI study.Experimental brain research · 2026Article
- The dorsolateral prefrontal cortex as a potential target for electrical stimulation in the treatment of vestibular-based nausea.The Journal of physiology · 2026Review
- The gut feeling in motion sickness.Communications biology · 2025Review
- Induced electric fields in MRI settings and electric vestibular stimulations: same vestibular effects?Experimental brain research · 2024Review
- The role of the dorsolateral prefrontal cortex in control of skin sympathetic nerve activity in humans.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Random-amplitude sinusoidal linear acceleration causes greater vestibular modulation of skin sympathetic nerve activity than constant-amplitude acceleration.Experimental brain research · 2018Article
- Vestibular Modulation of Sympathetic Nerve Activity to Muscle and Skin in Humans.Frontiers in neurology · 2017Review
- Vestibular Activation Habituates the Vasovagal Response in the Rat.Frontiers in neurology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that sinusoidal galvanic vestibular stimulation (sGVS), delivered bilaterally at frequencies of 0.08-2.00 Hz, causes a pronounced modulation of muscle sympathetic nerve activity (MSNA) and skin sympathetic nerve activity (SSNA), together with robust frequency-dependent illusions of side-to-side motion. At low frequencies of sGVS (≤0.2 Hz), some subjects report nausea, so we tested the hypothesis that vestibular modulation of MSNA and SSNA is augmented in individuals reporting nausea. MSNA was recorded via tungsten microelectrodes inserted into the left common peroneal nerve in 22 awake, seated subjects; SSNA was recorded in 14 subjects. Bipolar binaural sGVS (±2 mA, 100 cycles) was applied to the mastoid processes at 0.08, 0.13, and 0.18 Hz. Nausea was reported by 21 out of 36 subjects (58 %), but across frequencies of sGVS there was no difference in the magnitude of the vestibular modulation of MSNA in subjects who reported nausea (27.1 ± 1.8 %) and those who did not (30.4 ± 2.9 %). This contrasts with the significantly greater vestibular modulation of SSNA with nausea (41.1 ± 2.0 vs. 28.7 ± 3.1 %) and indicates an organ-specific modulation of sympathetic outflow via the vestibular system during motion sickness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.