ReviewJournal of muscle research and cell motility2015
MMP-14 in skeletal muscle repair.
Review in Journal of muscle research and cell motility, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Enzyme-regulated biomineralization: Biological functions and advanced biomaterials for tissue regeneration.Bioactive materials · 2026Review
- Transcriptomic analysis reveals the impact of concurrent, resistance, and endurance training on skeletal muscle.PloS one · 2026Article
- Gelatinase MMP Expression Is Correlated with Muscle Fiber Growth in Maiwa Yak Gluteus Maximus.Biological trace element research · 2025Article
- Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle.GeroScience · 2025Article
- Preliminary investigation of the effect of ferulic acid on miRNAs and LncRNAs in Mongolian horse skeletal muscle satellite cells.Frontiers in genetics · 2025Article
- Time-course and muscle-specific gene expression of matrix metalloproteinases and inflammatory cytokines in response to acute treadmill exercise in rats.Molecular biology reports · 2024Article
- Alignment, cross linking, and beyond: a collagen architect's guide to the skeletal muscle extracellular matrix.American journal of physiology. Cell physiology · 2023Review
- Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Metabolism: Insights into Health and Disease.International journal of molecular sciences · 2023Review
- Effects of Obesity in Old Age on the Basement Membrane of Skeletal Muscle in Mice.International journal of molecular sciences · 2023Article
- Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments.Molecular cancer · 2023Review
- Effects of stretching on the basement membrane structure in the soleus muscle of Wistar rats.Medical molecular morphology · 2023Article
- Diverse effector and regulatory functions of fibro/adipogenic progenitors during skeletal muscle fibrosis in muscular dystrophy.iScience · 2023Article
- Differential Fibrotic Response of Muscle Fibroblasts, Myoblasts, and Myotubes to Cholic and Deoxycholic Acids.Advances in experimental medicine and biology · 2023Article
- Novel Roles of MT1-MMP and MMP-2: Beyond the Extracellular Milieu.International journal of molecular sciences · 2022Review
- A muscle cell-macrophage axis involving matrix metalloproteinase 14 facilitates extracellular matrix remodeling with mechanical loading.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Amino Acids and IGF1 Regulation of Fish Muscle Growth Revealed by Transcriptome and microRNAome Integrative Analyses of Pacu (International journal of molecular sciences · 2022Article
- Actions and interactions of IGF-I and MMPs during muscle regeneration.Seminars in cell & developmental biology · 2021Review
- Effects of Endurance Exercise on Basement Membrane in the Soleus Muscle of Aged Rats.Acta histochemica et cytochemica · 2021Article
- Dynamic Expression of Membrane Type 1-Matrix Metalloproteinase (Mt1-mmp/Mmp14) in the Mouse Embryo.Cells · 2021Article
- Gene expression profile of adhesion and extracellular matrix molecules during early stages of skeletal muscle regeneration.Journal of cellular and molecular medicine · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MMP-14 (also known as MT1-MMP) is a membrane-bound collagenase and member of the Matrix Metalloprotease (MMP) family known to target a broad range of extracellular matrix (ECM) proteins. Remodelling of the ECM is of particular importance following skeletal muscle injury involving myofiber necrosis, when satellite cells are activated to facilitate myogenesis and regeneration. Myogenesis (broadly encompassed by the processes of satellite cell activation, proliferation, migration, differentiation and fusion) requires the myoblast to move either on or through a changing milieu of ECM components. The ECM composition, and especially the degree of fibrosis, influences ability of satellite cells to mediate a successful regenerative program. As a result, MMP activity is central to this regeneration; its activity increases following skeletal muscle injury, while inhibition of MMP reduces regeneration in this tissue. Besides its direct effect on matrix invasion, MMP-14 itself can affect this regeneration via activation of other MMPs (MMP-2, -9 and -13) as well as cytokines, chemokines and growth factors. Indeed recent research suggests that MMP-14 is necessary for the migration of human myoblasts into a collagen I matrix. Here we provide a current review on MMP-14 in the context of its role as a critical mediator of skeletal muscle regeneration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.