Evidence map›Paper›PMID 26025125›Full record

ArticleThe Journal of allergy and clinical immunology2015

Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent.

Marialbert Acosta-Herrera, Maria Pino-Yanes, Shwu-Fan Ma, Amalia Barreto-Luis, Almudena Corrales, José Cumplido, Eva Pérez-Rodríguez, Paloma Campo, Celeste Eng, José Carlos García-Robaina and 9 more

Abstract readLetter
In one paragraph

Article in The Journal of allergy and clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Mechanical Stress and Single Nucleotide Variants Regulate Alternative Splicing of the MYLK Gene.American journal of respiratory cell and molecular biology · 2017
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Marialbert Acosta-HerreraCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain; Multidisciplinary Organ Dysfunction Evaluation Research Network (MODERN), Research Unit, Hospital Universitario Dr. Negrin, Gran Canaria, Spain.
Maria Pino-YanesCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain; Department of Medicine, University of California, San Francisco, Calif.
Shwu-Fan MaSection of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Ill.
Amalia Barreto-LuisCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain.
Almudena CorralesCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain.
José CumplidoAllergy Unit, Hospital Universitario Dr. Negrin, Gran Canaria, Spain.
Eva Pérez-RodríguezAllergy Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain.
Paloma CampoU.G.C. Allergy, Regional University Hospital of Málaga-IBIMA, Málaga, Spain.
Celeste EngDepartment of Medicine, University of California, San Francisco, Calif.
José Carlos García-RobainaAllergy Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain.
Inés QuintelaGrupo de Medicina Xenómica, CEGEN-ISCIII-Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Jesús VillarCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Multidisciplinary Organ Dysfunction Evaluation Research Network (MODERN), Research Unit, Hospital Universitario Dr. Negrin, Gran Canaria, Spain.
Miguel BlancaU.G.C. Allergy, Regional University Hospital of Málaga-IBIMA, Málaga, Spain.
Ángel CarracedoGrupo de Medicina Xenómica, CIBERER-Universidade de Santiago de Compostela-Fundación Galega de Medicina Xenómica (SERGAS), Santiago de Compostela, Spain.
Teresa CarrilloAllergy Unit, Hospital Universitario Dr. Negrin, Gran Canaria, Spain.
Joe G N GarciaArizona Health Sciences Center, University of Arizona, Tucson, Ariz.
Dara G TorgersonDepartment of Medicine, University of California, San Francisco, Calif.
Esteban G BurchardDepartment of Medicine, University of California, San Francisco, Calif; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, Calif.
Carlos FloresCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain; Applied Genomics Group (G2A), Genetics Laboratory, Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Tenerife, Spain. Electronic address: cflores@ull.edu.es.

Funding

TRANSLATIONAL RESEARCH UNIVERSITY OF CHICAGO: CLINICAL TRIALSUL1RR024999 · NCRR · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2007 to 2011
$25.3M
Structure-Function Analysis of nmMLCK in EC Barrier ResponsesP01HL126609 · NHLBI · UNIVERSITY OF FLORIDA · PI Nathan A. Ellis · 2016 to 2026
$24.4M
New Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1M
The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3M
CLINICAL, PHARMACOLOGY, DRUG ACTION &PHARMACOKINETICST32GM007546 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Radojka Savic · 1985 to 2026
$8.9M
The EVE Asthma Genetics Consortium: Building Upon GWASRC2HL101651 · NHLBI · UNIVERSITY OF CHICAGO · PI NICOLAE, DAN LIVIU, OBER, CAROLE · 2009 to 2010
$7.4M
Social Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2012 to 2016
$6.4M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
Whole Genome Analyses for Asthma in Latino PopulationsR01HL088133 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$3.8M
Regulation of Asthmatic Inflammation by Non-Muscle MLCKR01HL091889 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GARCIA, JOE G. N., WANG, TING · 2008 to 2018
$3.2M
Case-control Association Studies and Genetic ConfoundingR01HL078885 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2005 to 2009
$1.9M
Genetics of Asthma In Latino AmericansK23HL004464 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2001 to 2005
$609k
NCRR NIH HHS UL1 RR024999NHLBI NIH HHS HL004464NHLBI NIH HHS HL078885NHLBI NIH HHS HL088133NHLBI NIH HHS HL101651NHLBI NIH HHS HL104608NHLBI NIH HHS HL117004NHLBI NIH HHS K23 HL004464NHLBI NIH HHS P01 HL126609NHLBI NIH HHS R01 HL078885NHLBI NIH HHS R01 HL088133NHLBI NIH HHS R01 HL091889NHLBI NIH HHS R01 HL104608NHLBI NIH HHS R01 HL117004NHLBI NIH HHS RC2 HL101651NIEHS NIH HHS ES015794NIEHS NIH HHS R01 ES015794NIGMS NIH HHS GM007546NIGMS NIH HHS T32 GM007546NIMHD NIH HHS MD006902NIMHD NIH HHS P60 MD006902
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Polymorphism, Single NucleotideAsthmaCalcium-Binding ProteinsChromosome MappingFemaleHumansMaleMyosin-Light-Chain KinaseSpainCalcium-Binding ProteinsMYLK protein, humanMyosin-Light-Chain Kinase

Identifiers

PMID26025125
PMCPMC4699578

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.