ArticleBMC pediatrics2015
Obesity in school-aged children and its correlation with gut E.coli and Bifidobacteria: a case-control study.
Article in BMC pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- The effect of antibiotics on the intestinal microbiota in children - a systematic review.Frontiers in allergy · 2024Pooled it
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- Influence of the Gut Microbiome on Body Composition and Metabolic Risk in Indian Children with Type 1 Diabetes Mellitus (T1dm).Journal of pharmacy & bioallied sciences · 2026Article
- TRENDS AND RESEARCH FRONTIERS ON GUT MICROBIOTA AND STUNTING: A BIBLIOMETRIC INSIGHT FROM 2009 TO 2025.Arquivos de gastroenterologia · 2026Article
- Lead exposure in relation to gut homeostasis, microbiota, and metabolites.Applied and environmental microbiology · 2025Review
- Persistent reduction ofFrontiers in immunology · 2025Article
- Protective Effect of Curcumin on Metabolic Syndrome Components through the Microbiota.Current medicinal chemistry · 2025Review
- Effects of a 217-km mountain ultramarathon on the gut microbiota of an obese runner: A case report.Physiological reports · 2024Article
- Gut microbiota and childhood malnutrition: Understanding the link and exploring therapeutic interventions.Engineering in life sciences · 2024Review
- Association between childhood obesity and gut microbiota: 16S rRNA gene sequencing-based cohort study.World journal of gastroenterology · 2024Article
- Probiotic Chocolate ContainingInternational journal of food science · 2024Article
- Review
- The infants' gut microbiome: setting the stage for the early onset of obesity.Frontiers in microbiology · 2024Article
- How Different Are the Influences of Mediterranean and Japanese Diets on the Gut Microbiome?Endocrine, metabolic & immune disorders drug targets · 2024Review
- Research trends between childhood obesity and gut microbiota: a bibliometric analysis (2002-2023).Frontiers in microbiology · 2024Review
- Exploring Gut Microbiota and the Influence of Physical Activity Interventions on Overweight and Obese Children and Adolescents: A Systematic Review.Healthcare (Basel, Switzerland) · 2023Review
- Bile Acids and Short-Chain Fatty Acids Are Modulated after Onion and Apple Consumption in Obese Zucker Rats.Nutrients · 2023Article
- Review
- Dynamic changes of fecal microbiota in a weight-change model of Bama minipigs.Frontiers in microbiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo determine the correlation between obesity in school-aged children and imbalance of gut microbes by examining the ratio change of intestinal Bifidobacteria and E.coli in obese children compared to non-obese controls.
methodsA hospital-based 1:1 case-control study was performed. Fecal samples of the subjects were collected for DNA extraction and analyzed by quantitative real-time PCR (qPCR) to determine the copy number of Bifidobacteria and E.coli. The ratio of two microbes (B/E) was then calculated and statistically analyzed.
resultsSubjects of the obesity group and control group showed no significant difference in age, gender or height (P > 0.05); whereas they had significant differences in body weight and BMI. Copy numbers of Bifidobacteria and E.coli per gram of wet fecal samples were first determined using qPCR in both obese and normal groups, which were further used for the calculation of B/E ratio. We found that B/E ration in the two groups showed significant difference (P < 0.05). Corrected χ(2) test was performed for the two groups against B/E < 1, and it was found that there was a positive correlation (OR = 719.2, OR 95% C.I. = 81.57-6341.18) between B/E ratio decrease with childhood obesity.
conclusionsThe obese children have a lower amount of Bifidobacteria and higher amount of E.coli (smaller B/E ratio) compared to normal non-obese children. It was suggested that obesity in children may be associated with the imbalance of gut microbes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.