ReviewAmerican journal of physiology. Heart and circulatory physiology2015
Neural control of circulation and exercise: a translational approach disclosing interactions between central command, arterial baroreflex, and muscle metaboreflex.
Review in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comparison of sarcopenia prevalence and prognostic features between HFrEF and HFpEF: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Prevalence of sarcopenia and its association with clinical outcomes in heart failure: An updated meta-analysis and systematic review.Clinical cardiology · 2023Pooled it
- Exercise training to reduce sympathetic nerve activity in heart failure patients. A systematic review and meta-analysis.Brazilian journal of physical therapyPooled it
- Time-series analysis of heart rate and blood pressure in response to changes in work rate before and after 60 days of 6° head down tilt bed rest.European journal of applied physiology · 2021Trial
- Study of heart rate recovery and cardiovascular autonomic modulation in healthy participants after submaximal exercise.Scientific reports · 2021Trial
- Exercise and Autonomic Cardiovascular Function-Insights From Spinal Cord-Injured Humans: A Narrative Review.Acta physiologica (Oxford, England) · 2026Review
- Heart rate recovery as a marker of post-exercise lipid metabolism following moderate- and vigorous-intensity exercise.European journal of applied physiology · 2026Article
- Whole-Brain Neural Connectivity to Cholinergic Neurons in the Lower Thoracic Intermediolateral Column.CNS neuroscience & therapeutics · 2026Article
- Research progress on the diagnosis and pathogenesis of chronic heart failure combined with sarcopenia.Journal of cardiothoracic surgery · 2026Review
- Physical activity and improvement of physiological parameters by training.Frontiers in sports and active living · 2026Review
- A controlled comparative study on the effect of arterial occlusion pressure on immediate sympathetic and hyperemic responses.Scientific reports · 2025Article
- The effects of exercise training on cardiovascular responses to muscle metaboreflex activation in patients after coronary artery bypass grafting.European journal of applied physiology · 2025Article
- From thought to action: The organization of spinal projecting neurons.Cell reports · 2025Review
- Neurocardiology: translational advancements and potential.The Journal of physiology · 2025Review
- Cardiac Baroreflex Is Preserved After the Recovery From COVID-19 Men and Women.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Amygdala-hypothalamus-brainstem circuits underlying cardiovascular responses associated with the limits of high-intensity endurance exercise.Frontiers in physiology · 2025Review
- Relationship between resting augmentation index and spontaneous cardiac baroreflex sensitivity during handgrip exercise in postmenopausal women.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- Effect of chronic exogenous oxytocin administration on exercise performance and cardiovagal control in hypobaric hypoxia in rats.Biological research · 2024Article
- Spinal projecting neurons in rostral ventromedial medulla co-regulate motor and sympathetic tone.Cell · 2024Article
- Cardiovascular responses to leg-press exercises during head-down tilt.Frontiers in sports and active living · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The last 100 years witnessed a rapid and progressive development of the body of knowledge concerning the neural control of the cardiovascular system in health and disease. The understanding of the complexity and the relevance of the neuroregulatory system continues to evolve and as a result raises new questions. The purpose of this review is to articulate results from studies involving experimental models in animals as well as in humans concerning the interaction between the neural mechanisms mediating the hemodynamic responses during exercise. The review describes the arterial baroreflex, the pivotal mechanism controlling mean arterial blood pressure and its fluctuations along with the two main activation mechanisms to exercise: central command (parallel activation of central somatomotor and autonomic descending pathways) and the muscle metaboreflex, the metabolic component of exercise pressor reflex (feedback from ergoreceptors within contracting skeletal muscles). In addition, the role of the cardiopulmonary baroreceptors in modulating the resetting of arterial baroreflex is identified, and the mechanisms in the central nervous system involved with the resetting of baroreflex function during dynamic exercise are also described. Approaching a very relevant clinical condition, the review also presents the concept that the impaired arterial baroreflex function is an integral component of the metaboreflex-mediated exaggerated sympathetic tone in subjects with heart failure. This increased sympathetic activity has a major role in causing the depressed ventricular function observed during submaximal dynamic exercise in these patients. The potential contribution of a metaboreflex arising from respiratory muscles is also considered.
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Registered trials
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