Evidence map›Paper›PMID 26024654›Full record

ArticleJournal of neuro-oncology2015

Incidence of vestibular schwannomas in the United States.

Varun R Kshettry, Jason K Hsieh, Quinn T Ostrom, Carol Kruchko, Jill S Barnholtz-Sloan

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
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  14. A Selection Protocol to Identify Therapeutics to Target NLRP3-Associated Sensory Hearing Loss.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2024
    Article
  15. Article
  16. Incidence of vestibular schwannoma in Finland, 1990-2017.Acta oncologica (Stockholm, Sweden) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Varun R KshettryDepartment of Neurosurgery, Neurological Institute, Cleveland Clinic, 9500 Euclid Ave, S40, Cleveland, OH, 44195, USA. varunkshettry@gmail.com.
Jason K HsiehCleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
Quinn T OstromCase Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Ave., Wearn 152, Cleveland, OH, 44106-5065, USA.
Carol KruchkoCentral Brain Tumor Registry of the United States, 244 East Ogden Ave, Suite 116, Hinsdale, IL, 60521, USA.
Jill S Barnholtz-SloanCase Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Ave., Wearn 152, Cleveland, OH, 44106-5065, USA. jsb42@case.edu.
Central Brain Tumor Registry of the United States · USCleveland Clinic Lerner College of Medicine · US

Funding

NCCDPHP CDC HHS 5U58DP00381-04
6 · The paper itself

Abstract

There is a paucity of population-based data evaluating the incidence of vestibular schwannomas according to age, gender, race, and ethnicity. Such data are necessary to assess the burden of vestibular schwannomas on varying populations and to inform future research and healthcare planning. The Central Brain Tumor Registry of the United States, which contains the largest aggregation of population-based data on the incidence of primary central nervous system tumors in the US, was used. Age-adjusted incidence rates and incidence rate ratios (IRR) of vestibular schwannomas from 2004 to 2010 were calculated by age at diagnosis, gender, race, and ethnicity. Annual percent change (APC) was calculated using Joinpoint to characterize temporal trends. From 2004 to 2010, there were 23,729 newly diagnosed vestibular schwannomas in the US; overall incidence was 1.09 per 100,000 population. Incidence was stable over time (APC -0.41 %, 95 % confidence interval -3.4, 2.7). Incidence increased with age to a peak of 2.93 per 100,000 in the 65-74 year old age group. Overall, there was no difference in incidence by gender. Compared to Whites, incidence was highest in Asian Pacific Islanders (IRR 1.37, p < 0.001) and lowest in African Americans (IRR 0.36, p < 0.001). Incidence was lower in Hispanics than non-Hispanics (IRR 0.69, p < 0.001). Over 3300 vestibular schwannomas are diagnosed per year in the US and incidence is 1.09 per 100,000 population. Incidence increases with age up to the 65-74 year old age group. Incidence is higher in Asian Pacific Islanders and lower in African Americans and Hispanics.

Indexed as

AdolescentAdultAgedAged, 80 and overAge FactorsChildChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornMaleMiddle AgedNeuroma, AcousticRacial GroupsAcoustic neuromaEpidemiologyIncidenceRaceVestibular schwannoma

Identifiers

PMID26024654
OpenAlexW885738793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.