ArticlePLoS neglected tropical diseases2015
Harnessing case isolation and ring vaccination to control Ebola.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Safety and Immunogenicity of a 2-Dose Heterologous Vaccine Regimen With Ad26.ZEBOV and MVA-BN-Filo Ebola Vaccines: 12-Month Data From a Phase 1 Randomized Clinical Trial in Nairobi, Kenya.The Journal of infectious diseases · 2019Trial
- How mathematical modelling can inform outbreak response vaccination.BMC infectious diseases · 2024Review
- Modeling the population-level impact of treatment on COVID-19 disease and SARS-CoV-2 transmission.Epidemics · 2022Article
- Article
- Analysis of COVID-19 Risk Following a Ring Vaccination Intervention to Address SARS-CoV-2 Alpha Variant Transmission in Montreal, Canada.JAMA network open · 2022Article
- Network models to evaluate vaccine strategies towards herd immunity in COVID-19.Journal of theoretical biology · 2021Article
- Protective population behavior change in outbreaks of emerging infectious disease.BMC infectious diseases · 2021Article
- Development and dissemination of infectious disease dynamic transmission models during the COVID-19 pandemic: what can we learn from other pathogens and how can we move forward?The Lancet. Digital health · 2021Review
- Article
- Review of mathematical models of HSV-2 vaccination: Implications for vaccine development.Vaccine · 2019Review
- Review
- Modelling microbial infection to address global health challenges.Nature microbiology · 2019Review
- Data Fitting and Scenario Analysis of Vaccination in the 2014 Ebola Outbreak in Liberia.Osong public health and research perspectives · 2019Article
- Ebola vaccination in the Democratic Republic of the Congo.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Modeling outbreak data: Analysis of a 2012 Ebola virus disease epidemic in DRC.Biomath (Sofia, Bulgaria) · 2019Article
- A large-scale location-based social network to understanding the impact of human geo-social interaction patterns on vaccination strategies in an urbanized area.Computers, environment and urban systems · 2018Article
- [Outbreak of Ébola in Lunsar. Effectiveness of a socio-sanitary intervention].Revista espanola de salud publica · 2018Article
- Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity.Journal of medicinal chemistry · 2018Article
- Role of contact tracing in containing the 2014 Ebola outbreak: a review.African health sciences · 2017Review
- Containing Ebola at the Source with Ring Vaccination.PLoS neglected tropical diseases · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
As a devastating Ebola outbreak in West Africa continues, non-pharmaceutical control measures including contact tracing, quarantine, and case isolation are being implemented. In addition, public health agencies are scaling up efforts to test and deploy candidate vaccines. Given the experimental nature and limited initial supplies of vaccines, a mass vaccination campaign might not be feasible. However, ring vaccination of likely case contacts could provide an effective alternative in distributing the vaccine. To evaluate ring vaccination as a strategy for eliminating Ebola, we developed a pair approximation model of Ebola transmission, parameterized by confirmed incidence data from June 2014 to January 2015 in Liberia and Sierra Leone. Our results suggest that if a combined intervention of case isolation and ring vaccination had been initiated in the early fall of 2014, up to an additional 126 cases in Liberia and 560 cases in Sierra Leone could have been averted beyond case isolation alone. The marginal benefit of ring vaccination is predicted to be greatest in settings where there are more contacts per individual, greater clustering among individuals, when contact tracing has low efficacy or vaccination confers post-exposure protection. In such settings, ring vaccination can avert up to an additional 8% of Ebola cases. Accordingly, ring vaccination is predicted to offer a moderately beneficial supplement to ongoing non-pharmaceutical Ebola control efforts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.