ArticlePloS one2015
Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Modifiable Nutritional Biomarkers in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis of Vitamin D, BInternational journal of molecular sciences · 2025Pooled it
- Pooled it
- Vitamin D-A Risk Factor for Bone Fractures in Children: A Population-Based Prospective Case-Control Randomized Cross-Sectional Study.International journal of environmental research and public health · 2023Trial
- The Association ofDiseases (Basel, Switzerland) · 2025Article
- Vitamin D Supplementation During Pregnancy and Maternal and Neonatal Vitamin D Status at ≤32 Weeks Gestation: Romanian Prospective Observational Cohort Study.Children (Basel, Switzerland) · 2025Article
- Retrospective Serologic Assessment of Vitamin D Levels in Children from Western Romania: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Vitamin D Deficiency: Insights and Perspectives from a Five-Year Retrospective Analysis of Children from Northeastern Romania.Nutrients · 2024Article
- Vitamin D Status among 2-18-Year-Old Romanian Pediatric Patients: A Single-Center Study.Nutrients · 2024Article
- Vitamin D-A New Therapeutic Target in the Management of Type 2 Diabetes Patients.Journal of clinical medicine · 2024Article
- Retrospective Analysis of Vitamin D Deficiency in an Adult Population of Arad County, Western Romania (2019-2022).Life (Basel, Switzerland) · 2024Article
- Relationship between Serum 25-Hydroxyvitamin D Levels and Hormonal Status in Infertile Women: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2023Article
- Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients.Diagnostics (Basel, Switzerland) · 2023Article
- 25 Hydroxyvitamin D Serum Concentration and COVID-19 Severity and Outcome-A Retrospective Survey in a Romanian Hospital.Nutrients · 2023Article
- Role of Dietary and Environmental Factors on Thyroid Cancer in Romania: A Brief Review.Diagnostics (Basel, Switzerland) · 2022Review
- Review
- Assessment of sun-related behavior and serum vitamin D in basal cell carcinoma: Preliminary results.Experimental and therapeutic medicine · 2020Article
- Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing.International journal of environmental research and public health · 2020Article
- Geomapping Vitamin D Status in a Large City and Surrounding Population-Exploring the Impact of Location and Demographics.Nutrients · 2020Article
- Vitamin D Levels of Out-Patients in Lithuania: Deficiency and Hypervitaminosis.Medicina (Kaunas, Lithuania) · 2018Article
- The association between the serum level of vitamin D and ischemic heart disease: a study from Jordan.Vascular health and risk management · 2018Observational
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Romania (latitude 48°15'N to 43°40'N), vitamin D supplementation is common practice mostly in infants 0-1 year old. No published information is available regarding epidemiological data on vitamin D status in the Romanian population for a wide age range and geographical territory. In this context, we aimed to evaluate the seasonal and age variation of vitamin D status in a large Romanian population.
methods6631 individuals from across Romania had performed 7544 vitamin D assessments (2012-2014) in a chain of private laboratories. Vitamin D (25-hydroxyvitamin D2 and 25-hydroxyvitamin D3) was measured using High Performance Liquid Chromatography. Vitamin D levels were classified as severe deficiency<10 ng/mL, deficiency 10-20 ng/mL, insufficiency 21-29 ng/mL, sufficiency ≥ 30 ng/mL and potentially harmful>100 ng/ml.
resultsMale to female ratio was 1:2.9. Age ranged from 0 to 85 years. Mean vitamin D levels increased from April (26.3n g/ml) to September (35.6 ng/ml) and decreased from October (33.5 ng/ml) to March (24.4 ng/ml). Overall 40% had sufficient vitamin D, while the rest were insufficient 33%, deficient 22%, severely deficient 4% and 1% potentially harmful (of them 81% under 1 year old). Males compared to females showed higher percentages of sufficiency (47% vs. 38%). Children 0- 2 years presented the highest percentage of vitamin D sufficiency (77%). Lowest percentages (21%) of sufficiency were in people 80-84 years.
conclusionIn Romania, suboptimal vitamin D levels are common (59%), especially in older age, wintertime and in women. Vitamin D supplementation would be most warranted from January to April in the Romanian population. 25-hydroxyvitamin D levels > 100 ng/ml were relatively prevalent in children 0-1 year old (17.3%). This was attributed to supplementation errors and the fact that high-risk individuals were more likely to visit for medical check-up. Nonetheless, it stresses the need to increase awareness of the importance of preventing Vitamin D supplementation administration errors in the young.
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