ArticleScientific reports2015
Resilience to orthostasis and haemorrhage: A pilot study of common genetic and conditioning mechanisms.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Cardiovascular phenotyping for personalized lifestyle treatments of chronic abdominal pain in Irritable Bowel Syndrome: A randomized pilot study.Neurogastroenterology and motility · 2019Trial
- Article
- Athletes' self-compassion and emotional resilience to failure: the mediating role of vagal reactivity.Frontiers in psychology · 2023Article
- Personalized behavior management as a replacement for medications for pain control and mood regulation.Scientific reports · 2021Article
- Relationship Between Haemostasis Parameters and Anxiety Under Examination Stress: A Pilot Study.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2018Article
- Merging current health care trends: innovative perspective in aging care.Clinical interventions in aging · 2018Article
- Orthostatic Challenge Shifts the Hemostatic System of Patients Recovered from Stroke toward Hypercoagulability.Frontiers in physiology · 2017Article
- Baroreflex mechanisms in Irritable Bowel Syndrome: Part I. Traditional indices.Physiology & behavior · 2016Article
- Central and peripheral pathogenetic forms of type 2 diabetes: a proof-of-concept study.Endocrine connections · 2016Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major challenge presently is not only to identify the genetic polymorphisms increasing risk to diseases, but to also find out factors and mechanisms, which can counteract a risk genotype by developing a resilient phenotype. The objective of this study was to examine acquired and innate vagal mechanisms that protect against physical challenges and haemorrhages in 19 athletes and 61 non-athletes. These include examining change in heart rate variability (HF-HRV; an indicator of vagus activity) in response to orthostatic challenge, platelet count (PLT), mean platelet volume (MPV), and single-nucleotide polymorphisms in genes that encode several coagulation factors, PAI-1, and MTHFR. Individual differences in PLT and MPV were significant predictors, with opposite effects, of the profiles of the HF-HRV changes in response to orthostasis. Regular physical training of athletes indirectly (through MPV) modifies the genetic predisposing effects of some haemostatic factors (PAI-1 and MTHFR) on vagal tone and reactivity. Individual differences in vagal tone were also associated with relationships between Factor 12 C46T and Factor 11 C22771T genes polymorphisms. This study showed that genetic predispositions for coagulation are modifiable. Its potential significance is promoting advanced protection against haemorrhages in a variety of traumas and injuries, especially in individuals with coagulation deficits.
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