Evidence map›Paper›PMID 26024315›Full record

ArticleOrganic letters2015

Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus.

Peng Fu, John B MacMillan

Open access · bronzeAbstract read
In one paragraph

Article in Organic letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Review
  3. MarineMarine drugs · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Peng FuDepartment of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, United States.
John B MacMillanDepartment of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, United States.
The University of Texas Southwestern Medical Center · US

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Sandi Leigh Pruitt · 2010 to 2026
$53.7M
Marine Actinomycetes as a Resource for Anticancer Natural ProductsR01CA149833 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MACMILLAN, JOHN B · 2010 to 2014
$1.6M
NCI NIH HHS P30 CA142543NCI NIH HHS R01 CA149833NCI NIH HHS R01CA1499833
6 · The paper itself

Abstract

Spithioneines A and B (1 and 2), two new bohemamine-type pyrrolizidine alkaloids possessing an unusual ergothioneine moiety, were isolated from a marine-derived Streptomyces spinoverrucosus. Their structures were elucidated by spectroscopic analysis, CD spectra, and chemical degradation and synthesis. Compounds 1 and 2 are rare natural products that incorporate the amino acid ergothioneine.

Indexed as

Biological ProductsErgothioneineMarine BiologyMolecular StructurePyrrolizidine AlkaloidsStreptomycesBiological ProductsbohemamineErgothioneinePyrrolizidine Alkaloidsspithioneine Aspithioneine B

Identifiers

PMID26024315
PMCPMC4892649
OpenAlexW2464147965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.