Evidence map›Paper›PMID 26024297›Full record

Trial reportNutrients2015

Blueberries improve endothelial function, but not blood pressure, in adults with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial.

April J Stull, Katherine C Cash, Catherine M Champagne, Alok K Gupta, Raymond Boston, Robbie A Beyl, William D Johnson, William T Cefalu

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 10 pooled it
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 10 syntheses or guidelines pooled it, 164 citations in OpenAlex.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

April J StullPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA. april.stull@pbrc.edu.
Katherine C CashPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA. katherinecash@gmail.com.
Catherine M ChampagnePennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA. catherine.champagne@pbrc.edu.
Alok K GuptaBaton Rouge VA Outpatient Clinic, Southeast Louisiana Veterans Health Care System, 7968 Essen Park Avenue, Baton Rouge, LA 70809, USA. alok.gupta1956@gmail.com.
Raymond BostonDepartment of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19348, USA. drrayboston@yahoo.com.
Robbie A BeylPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA. robbie.beyl@pbrc.edu.
William D JohnsonPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA. william.johnson@pbrc.edu.
William T CefaluPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA. william.cefalu@pbrc.edu.
Louisiana State University System · USPennington Biomedical Research Center · USSoutheast Louisiana Veterans Health Care System · USUniversity of Pennsylvania · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI JUDD E SHELLITO · 2012 to 2026
$69.1M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Sujoy Ghosh · 2005 to 2026
$26.5M
Pregnane and Glycosides and Obesity/llya RaskinP50AT002776 · NCCIH · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RASKIN, ILYA · 2005 to 2019
$24.9M
THE ROLE OF PROTEIN MALNUTRITION ON CIRCADIAN PHYSIOLOGY OF C57BL/6J MOUSE DAMSP20RR021945 · NCRR · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GETTYS, THOMAS W · 2006 to 2011
$9.5M
Bioactives in Blueberries and Insulin ResistanceK01AT006975 · NCCIH · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI STULL, APRIL · 2012 to 2016
$516k
NCCIH NIH HHS K01 AT006975NCCIH NIH HHS K01AT006975NCCIH NIH HHS P50 AT002776NCCIH NIH HHS P50AT002776-01NCRR NIH HHS P20 RR021945NCRR NIH HHS P20-RR021945NIDDK NIH HHS 1P30-DK072476NIDDK NIH HHS P30 DK072476NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Blueberry consumption has been shown to have various health benefits in humans. However, little is known about the effect of blueberry consumption on blood pressure, endothelial function and insulin sensitivity in humans. The present study investigated the role of blueberry consumption on modifying blood pressure in subjects with metabolic syndrome. In addition, endothelial function and insulin sensitivity (secondary measurements) were also assessed. A double-blind and placebo-controlled study was conducted in 44 adults (blueberry, n = 23; and placebo, n = 21). They were randomized to receive a blueberry or placebo smoothie twice daily for six weeks. Twenty-four-hour ambulatory blood pressure, endothelial function and insulin sensitivity were assessed pre- and post-intervention. The blood pressure and insulin sensitivity did not differ between the blueberry and placebo groups. However, the mean change in resting endothelial function, expressed as reactive hyperemia index (RHI), was improved significantly more in the group consuming the blueberries versus the placebo group (p = 0.024). Even after adjusting for confounding factors, i.e., the percent body fat and gender, the blueberry group still had a greater improvement in endothelial function when compared to their counterpart (RHI; 0.32 ± 0.13 versus -0.33 ± 0.14; p = 0.0023). In conclusion, daily dietary consumption of blueberries did not improve blood pressure, but improved (i.e., increased) endothelial function over six weeks in subjects with metabolic syndrome.

Indexed as

AdiposityBlood GlucoseBlood PressureBlood Pressure Monitoring, AmbulatoryBlueberry PlantsBody CompositionBody Mass IndexBody WeightCholesterolDouble-Blind MethodEndothelium, VascularFemaleFruitHumansInsulinInsulin ResistanceBlood GlucoseCholesterolInsulinTriglyceridesblueberriescardiovascular risk factorsendothelial dysfunctionendothelial functionhypertensionprediabetes

Identifiers

PMID26024297
PMCPMC4488775
OpenAlexW1491685106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.