Evidence map›Paper›PMID 26024215›Full record

ReviewCells2015

Recent advances in elucidating the genetic mechanisms of nephrogenesis using zebrafish.

Christina N Cheng, Valerie A Verdun, Rebecca A Wingert

Abstract readReview
In one paragraph

Review in Cells, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Frontiers in cell and developmental biology · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. eLife · 2018
    Article
  7. Review
  8. Article
  9. Article
  10. Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury.Journal of visualized experiments : JoVE · 2016
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christina N ChengDepartment of Biological Sciences, Center for Zebrafish Research, and Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA. ccheng2@nd.edu.
Valerie A VerdunDepartment of Biological Sciences, Center for Zebrafish Research, and Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA. verdunv12@alumni.nd.edu.
Rebecca A WingertDepartment of Biological Sciences, Center for Zebrafish Research, and Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA. rwingert@nd.edu.

Funding

Generation of novel models of kidney defects using the zebrafishR01DK100237 · NIDDK · UNIVERSITY OF NOTRE DAME · PI WINGERT, REBECCA ANN · 2013 to 2017
$1.8M
NIDDK NIH HHS R01 DK100237
6 · The paper itself

Abstract

The kidney is comprised of working units known as nephrons, which are epithelial tubules that contain a series of specialized cell types organized into a precise pattern of functionally distinct segment domains. There is a limited understanding of the genetic mechanisms that establish these discrete nephron cell types during renal development. The zebrafish embryonic kidney serves as a simplified yet conserved vertebrate model to delineate how nephron segments are patterned from renal progenitors. Here, we provide a concise review of recent advances in this emerging field, and discuss how continued research using zebrafish genetics can be applied to gain insights about nephrogenesis.

Indexed as

aPKChnf1ba/bkidney developmentmecomnephron segmentationrenal progenitorsim1atubulogenesisvertebratezebrafish

Identifiers

PMID26024215
PMCPMC4493457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.