Trial reportInvestigative ophthalmology & visual science2015
Photographic Reading Center of the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT): Methods and Baseline Results.
Trial report in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01003639 (A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss
Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Retinal vessel diameter changes after 6 months of treatment in the Idiopathic Intracranial Hypertension Treatment Trial.The British journal of ophthalmology · 2020Trial
- The Relationship Between Optic Disc Volume, Area, and Frisén Score in Patients With Idiopathic Intracranial Hypertension.American journal of ophthalmology · 2018Trial
- The Effect of Treatment of Idiopathic Intracranial Hypertension on Prevalence of Retinal and Choroidal Folds.American journal of ophthalmology · 2017Trial
- Papilledema Outcomes from the Optical Coherence Tomography Substudy of the Idiopathic Intracranial Hypertension Treatment Trial.Ophthalmology · 2015Trial
- Clinician-Led Code-Free Deep Learning for Detecting Papilledema and Pseudopapilledema Using Optic Disc Imaging.Translational vision science & technology · 2026Article
- Foveal Hypoplasia Grading with Optical Coherence Tomography: Agreement and Challenges Across Experience Levels.Diagnostics (Basel, Switzerland) · 2025Article
- Intracranial pressure affects retinal venular complexity in idiopathic intracranial hypertension: a retrospective observational study.BMC neurology · 2024Observational
- Idiopathic intracranial hypertension in Asians: a retrospective dual-center study.The journal of headache and pain · 2024Article
- Classifying and quantifying changes in papilloedema using machine learning.BMJ neurology open · 2024Article
- Bilateral optic disc infiltration in relapse of acute lymphoblastic leukemia.Indian journal of ophthalmology · 2022Article
- Optic Disc Edema and Elevated Intracranial Pressure (ICP): A Comprehensive Review of Papilledema.Cureus · 2022Review
- Linear interactions between intraocular, intracranial pressure, and retinal vascular pulse amplitude in the fourier domain.PloS one · 2022Article
- Variability of Retinal Vessel Tortuosity Measurements Using a Semiautomated Method Applied to Fundus Images in Subjects With Papilledema.Translational vision science & technology · 2021Article
- Accuracy of a Deep Learning System for Classification of Papilledema Severity on Ocular Fundus Photographs.Neurology · 2021Article
- OCT Based Interpretation of the Optic Nerve Head Anatomy and Prevalence of Optic Disc Drusen in Patients with Idiopathic Intracranial Hypertension (IIH).Life (Basel, Switzerland) · 2021Article
- Retinal Vein Changes as a Biomarker to Guide Diagnosis and Management of Elevated Intracranial Pressure.Frontiers in neurology · 2021Review
- A new novel method for assessing intracranial pressure using non-invasive fundus images: a pilot study.Scientific reports · 2020Observational
- Update on the Diagnosis and Treatment of Idiopathic Intracranial Hypertension.Seminars in neurology · 2019Review
- Retinal Vessel Diameters Change Within 1 Hour of Intracranial Pressure Lowering.Translational vision science & technology · 2018Article
- Retinal and Choroidal Folds in Papilledema.Investigative ophthalmology & visual science · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo describe the methods used by the Photographic Reading Center (PRC) of the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) and to report baseline assessments of papilledema severity in participants.
methodsStereoscopic digital images centered on the optic disc and the macula were collected using certified personnel and photographic equipment. Certification of the camera system included standardization and calibration using a model eye. Lay readers assessed disc photos of all eyes using the Frisén grade and performed quantitative measurements of papilledema. Frisén grades by PRC were compared with site investigator clinical grades. Spearman rank correlations were used to quantify associations among disc features and selected clinical variables.
resultsFrisén grades according to the PRC and site investigator's grades, matched exactly in 48% of the study eyes and 42% of the fellow eyes and within one grade in 94% of the study eyes and 92% of the fellow eyes. Frisén grade was strongly correlated (r > 0.65, P < 0.0001) with quantitative measures of disc area. Cerebrospinal fluid pressure was weakly associated with Frisén grade and disc area determinations (r ≤ 0.31). Neither Frisén grade nor any fundus feature was associated with perimetric mean deviation.
conclusionsIn a prospective clinical trial, lay readers agreed reasonably well with physicians in assessing Frisén grade. Standardization of camera systems enhanced consistency of photographic quality across study sites. Images were affected more by sensors with poor dynamic range than by poor resolution. Frisén grade is highly correlated with quantitative assessment of disc area. (ClinicalTrials.gov number, NCT01003639.).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.