ArticleInvestigative ophthalmology & visual science2015
Optical Coherence Tomography Angiography of Peripapillary Retinal Blood Flow Response to Hyperoxia.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed.
- Optical coherence tomography (OCT) in unconscious and systemically unwell patients using a mobile OCT device: a pilot study.BMJ open · 2019Trial
- Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults.PloS one · 2019Trial
- Association of hemispheric retinal oxygen extraction and macular plexus-specific capillary density in moderate to advanced glaucomatous hemifield defect.Scientific reports · 2025Article
- Retinochoroidal and Optic Nerve Head Microstructural and Microvascular Age-Related Changes in Healthy Eyes.Diagnostics (Basel, Switzerland) · 2025Article
- Retinal vessel density alteration after FS-LASIK for myopia with different axial lengths.International journal of ophthalmology · 2025Article
- Article
- Measurement of retinal blood flow precision in the human eye with multimodal adaptive optics imaging.Biomedical optics express · 2024Article
- Patterns of Structural Changes in the Fundus Measured by Optical Coherence Tomography Angiography as Potential Markers of Acute Mountain Sickness.Translational vision science & technology · 2023Article
- Analyses of the ratio of ganglion cell-inner plexiform layer thickness to vessel density according to age in healthy eyes.PloS one · 2023Article
- A Pilot Study Assessing Retinal Blood Flow Dysregulation in Glaucoma Using Erythrocyte Mediated Velocimetry.Translational vision science & technology · 2022Article
- Peripapillary Vascular Reactivity in Primary Open-Angle Glaucoma With High Myopia by Using Optical Coherence Tomography Angiography.Frontiers in medicine · 2022Article
- Retinal Microcirculatory Responses to Hyperoxia in Primary Open-Angle Glaucoma Using Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2021Article
- COVID-19 Associated Choroidopathy.Journal of clinical medicine · 2021Article
- Optical coherence tomography angiography findings in patients with COVID-19.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2021Article
- Pilot Study: Quantitative Photoacoustic Evaluation of Peripheral Vascular Dynamics Induced by Carfilzomib In Vivo.Sensors (Basel, Switzerland) · 2021Article
- Characterization of the Canine Retinal Vasculature With Optical Coherence Tomography Angiography: Comparisons With Histology and Fluorescein Angiography.Frontiers in neuroanatomy · 2021Article
- Reversed Neurovascular Coupling on Optical Coherence Tomography Angiography Is the Earliest Detectable Abnormality before Clinical Diabetic Retinopathy.Journal of clinical medicine · 2020Article
- Optical coherence tomography angiography characteristics of optic disc melanocytoma.BMC ophthalmology · 2020Article
- Caffeine Delays Retinal Neurovascular Coupling during Dark to Light Adaptation in Healthy Eyes Revealed by Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2020Article
- Optical coherence tomography angiography-derived flow density: a review of the influencing factors.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeTo measure the change in peripapillary retinal blood flow in response to hyperoxia by using optical coherence tomography (OCT) angiography.
methodsOne eye of each healthy human participants (six) was scanned with a commercial high-speed (70 kHz) spectral OCT. Scans were captured twice after 10-minute exposures to normal breathing (baseline) and hyperoxia. Blood flow was detected by the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm. Peripapillary retinal blood flow index and vessel density were calculated from en face maximum projections of the retinal layers. The experiment was performed on 2 separate days for each participant. Coefficient of variation (CV) was used to measure within-day repeatability and between-day reproducibility. Paired t-tests were used to compare means of baseline and hyperoxic peripapillary retinal blood flow.
resultsA decrease of 8.87% ± 3.09% (mean ± standard deviation) in flow index and 2.61% ± 1.50% in vessel density was observed under hyperoxia. The within-day repeatability CV of baseline measurements was 5.75% for flow index and 1.67% for vessel density. The between-day reproducibility CV for baseline flow index and vessel density was 11.1% and 1.14%, respectively. The between-day reproducibility of the hyperoxic response was 3.71% and 1.67% for flow index and vessel density, respectively.
conclusionsOptical coherence tomography angiography with SSADA was able to detect a decrease in peripapillary retinal blood flow in response to hyperoxia. The response was larger than the variability of baseline measurements. The magnitude of an individual's hyperoxic response was highly variable between days. Thus, reliable assessment may require averaging multiple measurements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.