ArticleInvestigative ophthalmology & visual science2015
Cross-coupled eye movement supports neural origin of pattern strabismus.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Amblyopia Severity Predicts Fixation Dysfunction Independent of Nystagmus and Foveation Disruption in Fusion Maldevelopment Nystagmus.Investigative ophthalmology & visual science · 2026Article
- Visually Guided Saccades in Amblyopia and Strabismus: The Roles of Sensory Deficits and Nystagmus.Investigative ophthalmology & visual science · 2026Article
- Saccade-Related Activity in Superior Colliculus Predicts Eye Choice for Goal-Directed Saccades in Monkeys With Strabismus.Investigative ophthalmology & visual science · 2025Article
- Disconjugacies of saccade duration and trajectories in strabismus.Strabismus · 2024Article
- Objective assessment of eye alignment and disparity-driven vergence in Parkinson's disease.Frontiers in aging neuroscience · 2023Article
- Microstimulation of Interstitial Nucleus of Cajal Evokes Directionally Disconjugate Eye Movements in Monkeys With Pattern Strabismus.Investigative ophthalmology & visual science · 2022Article
- The transcription factor Tbx5 regulates direction-selective retinal ganglion cell development and image stabilization.Current biology : CB · 2022Article
- Fixation eye movement abnormalities and stereopsis recovery following strabismus repair.Scientific reports · 2021Article
- Abnormal Tuning in Nucleus Prepositus Hypoglossi of Monkeys With "A" Pattern Exotropia.Investigative ophthalmology & visual science · 2020Article
- Abnormal Eye Position Signals in Interstitial Nucleus of Cajal in Monkeys With "A" Pattern Strabismus.Investigative ophthalmology & visual science · 2019Article
- Activity of near-response cells during disconjugate saccades in strabismic monkeys.Journal of neurophysiology · 2018Article
- Comparison of three models of saccade disconjugacy in strabismus.Journal of neurophysiology · 2017Article
- Neural mechanisms of oculomotor abnormalities in the infantile strabismus syndrome.Journal of neurophysiology · 2017Review
- Novel Eye Movement Disorders in Whipple's Disease-Staircase Horizontal Saccades, Gaze-Evoked Nystagmus, and Esotropia.Frontiers in neurology · 2017Article
- Normal correspondence of tectal maps for saccadic eye movements in strabismus.Journal of neurophysiology · 2016Article
- Strabismus and the Oculomotor System: Insights from Macaque Models.Annual review of vision science · 2016Article
- Electrical Microstimulation of the Superior Colliculus in Strabismic Monkeys.Investigative ophthalmology & visual science · 2016Article
- Saccades in progressive supranuclear palsy - maladapted, irregular, curved, and slow.Movement disorders clinical practiceArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposePattern strabismus describes vertically incomitant horizontal strabismus. Conventional theories emphasized the role of orbital etiologies, such as abnormal fundus torsion and misaligned orbital pulleys as a cause of the pattern strabismus. Experiments in animal models, however, suggested the role of abnormal cross-connections between the neural circuits. We quantitatively assessed eye movements in patients with pattern strabismus with a goal to delineate the role of neural circuits versus orbital etiologies.
methodsWe measured saccadic eye movements with high-precision video-oculography in 14 subjects with pattern strabismus, 5 with comitant strabismus, and 15 healthy controls. We assessed change in eye position in the direction orthogonal to that of the desired eye movement (cross-coupled responses). We used fundus photography to quantify the fundus torsion.
resultsWe found cross-coupling of saccades in all patients with pattern strabismus. The cross-coupled responses were in the same direction in both eyes, but larger in the nonviewing eye. All patients had clinically apparent inferior oblique overaction with abnormal excylotorsion. There was no correlation between the amount of the fundus torsion or the grade of oblique overaction and the severity of cross-coupling. The disconjugacy in the saccade direction and amplitude in pattern strabismics did not have characteristics predicted by clinically apparent inferior oblique overaction.
conclusionsOur results validated primate models of pattern strabismus in human patients. We found no correlation between ocular torsion or oblique overaction and cross-coupling. Therefore, we could not ascribe cross-coupling exclusively to the orbital etiology. Patients with pattern strabismus could have abnormalities in the saccade generators.
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