Evidence map›Paper›PMID 26024069›Full record

ArticleInvestigative ophthalmology & visual science2015

Effect of internal limiting membrane abrasion on retinal tissues in macular holes.

David R P Almeida, Eric K Chin, Ryan M Tarantola, James C Folk, H Culver Boldt, Jessica M Skeie, Robert F Mullins, Stephen R Russell, Vinit B Mahajan

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Internal limiting membrane peeling in macular hole surgery.German medical science : GMS e-journal · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Optimal management of idiopathic macular holes.Clinical ophthalmology (Auckland, N.Z.) · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

David R P AlmeidaDepartment of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States.
Eric K ChinDepartment of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States.
Ryan M TarantolaDepartment of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States.
James C FolkDepartment of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States.
H Culver BoldtDepartment of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States.
Jessica M SkeieDepartment of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States 2Omics Laboratory, Iowa City, Iowa, United States.
Robert F MullinsDepartment of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States.
Stephen R RussellDepartment of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States.
Vinit B MahajanDepartment of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States 2Omics Laboratory, Iowa City, Iowa, United States.
University of Iowa Hospitals and Clinics · US

Funding

Molecular Genetics of Dominant Neovascular Inflammatory VitreoretinopathyK08EY020530 · NEI · UNIVERSITY OF IOWA · PI MAHAJAN, VINIT B · 2011 to 2015
$1.1M
NEI NIH HHS K08 EY020530NEI NIH HHS K08EY020530
6 · The paper itself

Abstract

purposeThe purpose of this study was to identify the structural and histological effects of a Tano diamond-dusted membrane scraper (DDMS) on the retinal surface after internal limiting membrane (ILM) abrasion in macular hole surgery.

methodsInstitutional experimental study was performed in 11 eyes. All eyes underwent ILM abrasion in the operating room with a DDMS for macular hole repair as an alternative to traditional ILM peeling. Three human donor eyes underwent an identical procedure in the laboratory. Retinal tissues were removed by ILM abrasion with a DDMS during vitrectomy for macular hole repair and retinal tissues remaining in human donor eyes. Main outcome measures were microscopic and immunohistological characteristics of instrument tip tissues and retinal structure after ILM abrasion.

resultsThe tips of the Tano DDMS showed evidence of cellular membranes and ILM removal. The retinas showed distinct areas of lamellar ILM removal without penetration of the retinal nerve fiber layer (RNFL).

conclusionsApplication of the Tano DDMS instrument is sufficient to remove membranes from the surface of the ILM and layers of the ILM without disruption of the underlying RNFL. Internal limiting membrane abrasion can be a useful and effective alternative to complete ILM removal for macular surgery.

Indexed as

AgedEpiretinal MembraneFemaleHumansMacula LuteaMaleMicroscopy, Electrochemical, ScanningMiddle AgedRetinal PerforationsVitrectomy

Identifiers

PMID26024069
PMCPMC4416746
OpenAlexW2403244986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.