Evidence map›Paper›PMID 26023781›Full record

ArticlePloS one2015

Seasonal effects on gene expression.

Anita Goldinger, Konstantin Shakhbazov, Anjali K Henders, Allan F McRae, Grant W Montgomery, Joseph E Powell

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Anita GoldingerUniversity of Queensland Diamantina Institute, The Translational Research Institute, Brisbane, Queensland 4102, Australia; The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia.
Konstantin ShakhbazovUniversity of Queensland Diamantina Institute, The Translational Research Institute, Brisbane, Queensland 4102, Australia.
Anjali K HendersThe Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia; Queensland Institute of Medical Research, Herston, Brisbane, QLD 4006, Australia.
Allan F McRaeUniversity of Queensland Diamantina Institute, The Translational Research Institute, Brisbane, Queensland 4102, Australia; The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia; Queensland Institute of Medical Research, Herston, Brisbane, QLD 4006, Australia.
Grant W MontgomeryQueensland Institute of Medical Research, Herston, Brisbane, QLD 4006, Australia.
Joseph E PowellThe Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia.
University of Queensland · AUQIMR Berghofer Medical Research Institute · AU

Funding

NIGMS NIH HHS GM057091
6 · The paper itself

Abstract

Many health conditions, ranging from psychiatric disorders to cardiovascular disease, display notable seasonal variation in severity and onset. In order to understand the molecular processes underlying this phenomenon, we have examined seasonal variation in the transcriptome of 606 healthy individuals. We show that 74 transcripts associated with a 12-month seasonal cycle were enriched for processes involved in DNA repair and binding. An additional 94 transcripts demonstrated significant seasonal variability that was largely influenced by blood cell count levels. These transcripts were enriched for immune function, protein production, and specific cellular markers for lymphocytes. Accordingly, cell counts for erythrocytes, platelets, neutrophils, monocytes, and CD19 cells demonstrated significant association with a 12-month seasonal cycle. These results demonstrate that seasonal variation is an important environmental regulator of gene expression and blood cell composition. Notable changes in leukocyte counts and genes involved in immune function indicate that immune cell physiology varies throughout the year in healthy individuals.

Indexed as

SeasonsHumansLeukocyte CountMonocytesNeutrophilsTranscriptome

Identifiers

PMID26023781
PMCPMC4449160
OpenAlexW387297489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.