ArticlePloS one2015
Studying Cat (Felis catus) Diabetes: Beware of the Acromegalic Imposter.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- iCatCare 2025 consensus guidelines on the diagnosis and management of diabetes mellitus in cats.Journal of feline medicine and surgery · 2025Guideline
- Type 2 Diabetes Mellitus in the Northern Tree Shrew (Tupaia belangeri).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Evaluating the correlation between serum fructosamine concentration and interstitial glucose concentration in cats with diabetes mellitus.Journal of veterinary internal medicine · 2026Article
- Association of inflammation with glycemic control, insulin sensitivity, and beta-cell function in diabetic cats.Journal of veterinary internal medicine · 2026Article
- Owner points of view and perceived quality of life of diabetic cats pre- and post-hypophysectomy for hypersomatotropism.Journal of veterinary internal medicine · 2026Article
- Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024).Journal of veterinary internal medicine · 2026Article
- Case Report: Treatment of hypersomatotropism in a diabetic dog with transsphenoidal hypophysectomy.Frontiers in veterinary science · 2026Article
- Hypersomatotropism in diabetic cats in Australia.Journal of feline medicine and surgery · 2025Article
- Associations between body composition, metabolic mediators and osteoarthritis in cats.BMC veterinary research · 2025Article
- SGLT2 inhibitor use in the management of feline diabetes mellitus.Journal of veterinary pharmacology and therapeutics · 2025Review
- Signalment, clinicopathological findings, management practices and comorbidities in cats with diabetes mellitus in Germany: cross-sectional study of 144 cases.Journal of feline medicine and surgery · 2025Article
- Feline Comorbidities: Hypersomatotropism-induced diabetes in cats.Journal of feline medicine and surgery · 2024Review
- Method Validation and Establishment of Reference Intervals for an Insulin-like Growth Factor-1 Chemiluminescent Immunoassay in Cats.Veterinary sciences · 2023Article
- Pets, Genuine Tools of Environmental Pollutant Detection.Animals : an open access journal from MDPI · 2023Review
- Computed Tomographic Assessment of Pituitary Gland Dimensions in Domestic Short-Haired Cats.Animals : an open access journal from MDPI · 2023Article
- Prevalence of hypersomatotropism and hyperthyroidism in cats with diabetes mellitus from referral centers in Buenos Aires (2020-2022).Journal of feline medicine and surgery · 2023Article
- Survival, remission, and quality of life in diabetic cats.Journal of veterinary internal medicine · 2023Article
- Cabergoline treatment in cats with diabetes mellitus and hypersomatotropism.Journal of feline medicine and surgery · 2022Article
- Therapy for feline secondary hypertriglyceridemia with fenofibrate.Journal of feline medicine and surgery · 2022Article
- Quality of life and response to treatment in cats with hypersomatotropism: the owners' point of view.Journal of feline medicine and surgery · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Naturally occurring diabetes mellitus (DM) is common in domestic cats (Felis catus). It has been proposed as a model for human Type 2 DM given many shared features. Small case studies demonstrate feline DM also occurs as a result of insulin resistance due to a somatotrophinoma. The current study estimates the prevalence of hypersomatotropism or acromegaly in the largest cohort of diabetic cats to date, evaluates clinical presentation and ease of recognition. Diabetic cats were screened for hypersomatotropism using serum total insulin-like growth factor-1 (IGF-1; radioimmunoassay), followed by further evaluation of a subset of cases with suggestive IGF-1 (>1000 ng/ml) through pituitary imaging and/ or histopathology. Clinicians indicated pre-test suspicion for hypersomatotropism. In total 1221 diabetic cats were screened; 319 (26.1%) demonstrated a serum IGF-1>1000 ng/ml (95% confidence interval: 23.6-28.6%). Of these cats a subset of 63 (20%) underwent pituitary imaging and 56/63 (89%) had a pituitary tumour on computed tomography; an additional three on magnetic resonance imaging and one on necropsy. These data suggest a positive predictive value of serum IGF-1 for hypersomatotropism of 95% (95% confidence interval: 90-100%), thus suggesting the overall hypersomatotropism prevalence among UK diabetic cats to be 24.8% (95% confidence interval: 21.2-28.6%). Only 24% of clinicians indicated a strong pre-test suspicion; most hypersomatotropism cats did not display typical phenotypical acromegaly signs. The current data suggest hypersomatotropism screening should be considered when studying diabetic cats and opportunities exist for comparative acromegaly research, especially in light of the many detected communalities with the human disease.
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