ArticlePloS one2015
The NMDA Receptor Promotes Sleep in the Fruit Fly, Drosophila melanogaster.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 70 citations in OpenAlex.
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- The Glutamate-gated Chloride Channel Facilitates Sleep by Enhancing the Excitability of Two Pairs of Neurons in the Ventral Nerve Cord of Drosophila.Neuroscience bulletin · 2025Article
- Role of d-serine in intestinal ROS accumulation after sleep deprivation.Science advances · 2025Article
- Insight into molecular and neural mechanisms of general anesthesia from the invertebrate modelZoological research · 2025Review
- Deciphering Post-Stroke Sleep Disorders: Unveiling Neurological Mechanisms in the Realm of Brain Science.Brain sciences · 2024Review
- Road to sexual maturity: Behavioral event schedule from eclosion to first mating in each sex ofiScience · 2023Article
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- The relationship between sleep, dissociation and psychotic-like experiences.Early intervention in psychiatry · 2022Article
- Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila.Current biology : CB · 2022Article
- NMDA Receptors in the Lateral Preoptic Hypothalamus Are Essential for Sustaining NREM and REM Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The role of calcium and CaMKII in sleep.Frontiers in systems neuroscience · 2022Review
- Light exposure during development affects physiology of adults inFrontiers in physiology · 2022Article
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- Associative learning in larval and adult Drosophila is impaired by the dopamine-synthesis inhibitor 3-Iodo-L-tyrosine.Biology open · 2021Article
- Protocerebral Bridge Neurons That Regulate Sleep inFrontiers in neuroscience · 2021Article
- An Overview of the Involvement of D-Serine in Cognitive Impairment in Normal Aging and Dementia.Frontiers in psychiatry · 2021Review
- Investigating Developmental and Epileptic Encephalopathy UsingInternational journal of molecular sciences · 2020Review
- Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Considerable evidence indicates that sleep is essential for learning and memory. Drosophila melanogaster has emerged as a novel model for studying sleep. We previously found a short sleeper mutant, fumin (fmn), and identified its mutation in the dopamine transporter gene. We reported similarities in the molecular basis of sleep and arousal regulation between mammals and Drosophila. In aversive olfactory learning tasks, fmn mutants demonstrate defective memory retention, which suggests an association between sleep and memory. In an attempt to discover additional sleep related genes in Drosophila, we carried out a microarray analysis comparing mRNA expression in heads of fmn and control flies and found that 563 genes are differentially expressed. Next, using the pan-neuronal Gal4 driver elav-Gal4 and UAS-RNA interference (RNAi) to knockdown individual genes, we performed a functional screen. We found that knockdown of the NMDA type glutamate receptor channel gene (Nmdar1) (also known as dNR1) reduced sleep. The NMDA receptor (NMDAR) plays an important role in learning and memory both in Drosophila and mammals. The application of the NMDAR antagonist, MK-801, reduced sleep in control flies, but not in fmn. These results suggest that NMDAR promotes sleep regulation in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.