ArticleInternational journal of molecular sciences2015
The cross-bridge of skeletal muscle is not synchronized either by length or force step.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Force and length steps, applied to a muscle fiber in the isometric state, are believed to synchronize attached cross-bridges. This alleged synchronization facilitates the interpretation of the experiments. A rapid force step elicits an elastic response of the attached cross-bridges, followed by an isotonic phase. The decay of this second isotonic phase is of the first order. This excludes that the attached cross-bridges may decay all at the same time. The change of the X-ray interference distance during the second phase measures the stroke size only in the unrealistic case that the cross-bridges are and remain all attached. A rapid force step does not synchronize attached cross-bridges. The change of X-ray interference during the second phase does not measure the stroke size. These conclusions significantly change the picture of the mechanism of skeletal muscle contraction.
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