Evidence map›Paper›PMID 26023681›Full record

ArticleEBioMedicine2015

Use of Whole Genome Sequencing for Diagnosis and Discovery in the Cancer Genetics Clinic.

Samantha B Foley, Jonathan J Rios, Victoria E Mgbemena, Linda S Robinson, Heather L Hampel, Amanda E Toland, Leslie Durham, Theodora S Ross

Open access · goldAbstract read
In one paragraph

Article in EBioMedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Review
  3. The breast journal · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Whole-Genome Sequencing in Cancer.Cold Spring Harbor perspectives in medicine · 2019
    Review
  14. Article
  15. Article
  16. Review
  17. THE GORDON WILSON LECTURE: CANCER GENE VARIANT (RE)CLASSIFICATION: FROM TRUTHINESS TO TRUTH.Transactions of the American Clinical and Climatological Association · 2018
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Samantha B FoleyDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas TX, 75390, USA.
Jonathan J RiosSarah M. and Charles E. Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, Texas 75219, USA ; Department of Pediatrics, McDermott Center for Human Growth and Development, and Department of Orthopaedic Surgery, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
Victoria E MgbemenaDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas TX, 75390, USA.
Linda S RobinsonDepartment of Cancer Genetics, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Heather L HampelDepartment of Human Genetics, Ohio State University, Columbus, OH, 43210, USA.
Amanda E TolandDepartment of Human Genetics, Ohio State University, Columbus, OH, 43210, USA.
Leslie DurhamDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas TX, 75390, USA ; Sarah M. and Charles E. Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, Texas 75219, USA.
Theodora S RossDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas TX, 75390, USA ; Department of Cancer Genetics, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Southwestern Medical CenterThe Ohio State University · USSouthwestern Medical Center · USTexas Scottish Rite Hospital for Children · USThe University of Texas Southwestern Medical Center · US

Funding

UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
Cancer Biology Training GrantT32CA124334 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAY, JERRY WILLIAM · 2007 to 2021
$5.3M
Huntington Interacting Protein-1(HIP1) and the Promotion of NeoplasiaR01CA098730 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI ROSS, THEODORA S · 2003 to 2012
$2.6M
NCATS NIH HHS UL1 TR001105NCI NIH HHS R01 CA098730NCI NIH HHS T32 CA124334
6 · The paper itself

Abstract

Despite the potential of whole-genome sequencing (WGS) to improve patient diagnosis and care, the empirical value of WGS in the cancer genetics clinic is unknown. We performed WGS on members of two cohorts of cancer genetics patients: those with

Indexed as

BRCA1/2Cancer geneticsClinVarPathogenic variantsSingle nucleotide variantWhole-genome sequence

Identifiers

PMID26023681
PMCPMC4444225
OpenAlexW2021273750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.