Evidence map›Paper›PMID 26023450›Full record

ArticleJournal of neonatal surgery

Gastrointestinal perforation in neonates: aetiology and risk factors.

Ekwunife Okechukwu Hyginus, Ugwu Jideoffor, Modekwe Victor, Osuigwe Andrew N

Open access · greenAbstract read
In one paragraph

Article in Journal of neonatal surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Necrotizing enterocolitis with gastric perforation in a 24-day old preterm neonate.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026
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  12. Delayed diagnosis of spontaneous intestinal perforation among very low birth weight neonates: A single center experience.Journal of perinatology : official journal of the California Perinatal Association · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ekwunife Okechukwu HyginusPaediatric Surgery Unit, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria.
Ugwu JideofforPaediatric Surgery Unit, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria.
Modekwe VictorPaediatric Surgery Unit, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria.
Osuigwe Andrew NPaediatric Surgery Unit, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria.
Nnamdi Azikiwe University Teaching Hospital · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastrointestinal perforation (GIP) in neonates presents important challenges and mortality can be high. This is a report of recent experience with GIP in neonates in a developing country. PATIENTS AND

methodsA retrospective review of 16 neonates treated for GIP in a 3 year period.

resultsThere were 9 males and 7 females, aged 0-28 days (median age =7days). Their weights at presentation ranged from 0.9 - 4.7kg (median =2.6). Five infants were premature. Twelve infants presented more than 72 hours after onset of symptoms. Plain abdominal radiographs showed peumoperitoneum in 9 infants. The cause of perforation was necrotising enterocolitis 6, intestinal obstruction 6, iatrogenic 3 and spontaneous 1. The site of perforation was ileum in 12 infants, stomach in 4 and colon in 4; 4 patients had involvement of more than one site. All the neonates underwent exploratory laparotomy with primary closure ( n=5) , resection and anastomosis( n=6), colostomy (n=3), Ileostomy ( n=2), partial gastrectomy (n=2) ,or gastrojejunostomy ( n=1). Two neonates had multiple procedures. Two very sick preterm babies had an initial peritoneal lavage. Surgical site infection is the commonest postoperative complication occurring in 9 infants. Anaesthesia sepsis and malnutrition is responsible for the seven deaths recorded.

conclusionsNeonatal GIP has multiple aetiologies; NEC is the most common cause. Major mortality risk factors include NEC, multiple perforations, delayed presentation and prematurity.

Indexed as

AetiologyIntestineNeonatePerforation

Identifiers

PMID26023450
PMCPMC4422271
OpenAlexW2168333093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.