ArticleIranian Red Crescent medical journal2015
Urinary metabonomics for diagnosis of depression in hepatitis B virus-infected patients.
Article in Iranian Red Crescent medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Metabolomic Profiling of Cerebrospinal Fluid Reveals Metabolite Biomarkers in Tick-Borne Encephalitis Patient.Journal of medical virology · 2024Article
- Circulating metabolites and depression: a bidirectional Mendelian randomization.Frontiers in neuroscience · 2023Article
- Metabonomic Profile and Signaling Pathway Prediction of Depression-Associated Suicidal Behavior.Frontiers in psychiatry · 2020Article
- Dual Metabolomic Platforms Identified a Novel Urinary Metabolite Signature for Hepatitis B Virus-Infected Patients with Depression.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Urinary biomarker panel for diagnosing patients with depression and anxiety disorders.Translational psychiatry · 2018Article
- Article
- Noninvasive metabolic profiling for painless diagnosis of human diseases and disorders.Future science OA · 2016Review
- Psychological Reactions among Patients with Chronic Hepatitis B: a Qualitative Study.Journal of caring sciences · 2016Article
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Authors and funding
7 authors.
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Abstract
backgroundDepression is concomitantly presented in Hepatitis B Virus (HBV)-infected patients and decreases these patients' quality of life. However, there are no laboratory-based methods to objectively diagnose this disorder.
objectivesThe aim of this study was to investigate the alteration of urinary metabolites in depressed HBV-infected patients. PATIENTS AND
methodsIn this study, 81 depressed HBV-infected patients, 68 non-depressed HBV-infected patients and 64 Healthy Controls (HC) were recruited. A nuclear magnetic resonance (NMR)-based urinary metabonomic method was used to characterize the urinary metabolic profiling of depressed and non-depressed subjects.
resultsSeventeen differential urinary metabolites responsible for discriminating depressed HBV-infected patients from non-depressed HBV-infected patients and HC were identified. Among these metabolites, pyruvate, isobutyrate, N-methylnicotinamide, α-hydroxybutyrate, acetoacetate and malonate were identified as potential biomarkers for diagnosing depression in HBV-infected patients. A combined panel of these potential biomarkers could effectively discriminate depressed HBV-infected patients from non-depressed HBV-infected patients and HC, with an average accuracy of 89.6% in the training set and a predictive accuracy of 86.4% in the test set.
conclusionsThese findings suggest that NMR-based urinary metabonomics approach might be a useful tool for the clinical diagnosis of depression in HBV-infected patients and the six potential biomarkers could be helpful for developing an objective diagnostic method. Limited by the number of recruited subjects, future studies are required to validate our conclusions.
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