Evidence map›Paper›PMID 26023329›Full record

ArticleJournal of animal science and biotechnology2015

Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period.

Haichao Zhao, Linlin Sui, Kai Miao, Lei An, Dong Wang, Zhuocheng Hou, Rui Wang, Min Guo, Zhilong Wang, Jiqiang Xu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science and biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Haichao Zhao *Ministry of Agriculture Key Laboratory of Animal Genetics, Breeding and Reproduction, National engineering laboratory for animal breeding, College of Animal Sciences and Technology, China Agricultural University, No.2 Yuanmingyuan Xi Lu, Haidian, Beijing, 100193 China.
Linlin Sui *Ministry of Agriculture Key Laboratory of Animal Genetics, Breeding and Reproduction, National engineering laboratory for animal breeding, College of Animal Sciences and Technology, China Agricultural University, No.2 Yuanmingyuan Xi Lu, Haidian, Beijing, 100193 China.
Kai MiaoMinistry of Agriculture Key Laboratory of Animal Genetics, Breeding and Reproduction, National engineering laboratory for animal breeding, College of Animal Sciences and Technology, China Agricultural University, No.2 Yuanmingyuan Xi Lu, Haidian, Beijing, 100193 China.
Lei AnMinistry of Agriculture Key Laboratory of Animal Genetics, Breeding and Reproduction, National engineering laboratory for animal breeding, College of Animal Sciences and Technology, China Agricultural University, No.2 Yuanmingyuan Xi Lu, Haidian, Beijing, 100193 China.
Dong WangThe Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agriculture Sciences, Beijing, 100193 China.
Zhuocheng HouNational Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, China Agricultural University, Beijing, 100193 China.
Rui WangMinistry of Agriculture Key Laboratory of Animal Genetics, Breeding and Reproduction, National engineering laboratory for animal breeding, College of Animal Sciences and Technology, China Agricultural University, No.2 Yuanmingyuan Xi Lu, Haidian, Beijing, 100193 China.
Min GuoMinistry of Agriculture Key Laboratory of Animal Genetics, Breeding and Reproduction, National engineering laboratory for animal breeding, College of Animal Sciences and Technology, China Agricultural University, No.2 Yuanmingyuan Xi Lu, Haidian, Beijing, 100193 China.
Zhilong WangMinistry of Agriculture Key Laboratory of Animal Genetics, Breeding and Reproduction, National engineering laboratory for animal breeding, College of Animal Sciences and Technology, China Agricultural University, No.2 Yuanmingyuan Xi Lu, Haidian, Beijing, 100193 China.
Jiqiang XuCollege of Animal Science and Technology, Agricultural University of Hebei, Baoding, Hebei 071000 People's Republic of China.
Zhonghong WuState Key Laboratory of Animal Nutrition, College of Animal Sciences and Technology, China Agricultural University, No.2 Yuanmingyuan Xi Lu, Haidian, Beijing, 100193 China.
Jianhui TianMinistry of Agriculture Key Laboratory of Animal Genetics, Breeding and Reproduction, National engineering laboratory for animal breeding, College of Animal Sciences and Technology, China Agricultural University, No.2 Yuanmingyuan Xi Lu, Haidian, Beijing, 100193 China.
China Agricultural University · CNChinese Academy of Agricultural Sciences · CNHebei Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly pregnancy failure has a profound impact on both human reproductive health and animal production. 2/3 pregnancy failures occur during the peri-implantation period; however, the underlying mechanism(s) remains unclear. Well-organized modification of the endometrium to a receptive state is critical to establish pregnancy. Aberrant endometrial modification during implantation is thought to be largely responsible for early pregnancy loss.

resultIn this study, using well-managed recipient ewes that received embryo transfer as model, we compared the endometrial proteome between pregnant and non-pregnant ewes during implantation period. After embryo transfer, recipients were assigned as pregnant or non-pregnant ewes according to the presence or absence of an elongated conceptus at Day 17 of pregnancy. By comparing the endometrial proteomic profiles between pregnant and non-pregnant ewes, we identified 94 and 257 differentially expressed proteins (DEPs) in the endometrial caruncular and intercaruncular areas, respectively. Functional analysis showed that the DEPs were mainly associated with immune response, nutrient transport and utilization, as well as proteasome-mediated proteolysis.

conclusionThese analysis imply that dysfunction of these biological processes or pathways of DEP in the endometrium is highly associated with early pregnancy loss. In addition, many proteins that are essential for the establishment of pregnancy showed dysregulation in the endometrium of non-pregnant ewes. These proteins, as potential candidates, may contribute to early pregnancy loss.

Indexed as

Early pregnancy lossEndometriumEweLC-MS/MSProteome

Identifiers

PMID26023329
PMCPMC4447021
OpenAlexW2019982322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.