ReviewJournal of applied physiology (Bethesda, Md. : 1985)2016
Skeletal muscle vasodilation during systemic hypoxia in humans.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Pooled it
- Cardiorespiratory and oxygenation responses in iron-deficient anemic women during whole-body exercise under moderate hypoxia.European journal of applied physiology · 2026Trial
- β-Adrenergic receptors mediate sex differences in vasodilation but not sympathetic-mediated vasoconstriction during hypoxia.American journal of physiology. Heart and circulatory physiology · 2025Trial
- Trial
- Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia.Clinical pharmacology and therapeutics · 2018Trial
- Acute ingestion of dietary nitrate increases muscle blood flow via local vasodilation during handgrip exercise in young adults.Physiological reports · 2018Trial
- Macro- and microcirculatory factors affecting foot temperature change during walking.Experimental physiology · 2026Article
- Exercise in acute and subacute hypoxic conditions: physiological responses affecting oxygen delivery and their applications to human health.The Journal of physiology · 2026Review
- The effect of sex on the isolated and combined α- and β-adrenergic control of blood flow during handgrip in adults at high altitude: An exploratory study.Physiological reports · 2026Article
- Susceptibility to mild and severe acute mountain sickness is associated with distinct urine metabolite profiles.Frontiers in physiology · 2026Article
- Renal Metabolic Rate of Oxygen in Response to Hypoxia Challenges by Means of Quantitative MRI in Humans.NMR in biomedicine · 2025Article
- Critical power and critical oxygenation: examining transferability between normoxia and hypoxia.European journal of applied physiology · 2025Article
- The combined effects of artificial gravity, temperature, and hypoxia on haemodynamic responses and limb blood flow.European journal of applied physiology · 2025Article
- Role of overweight and obesity on vascular responses to the cold pressor test and hypoxia in women.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Effects of a Three-Day vs. Six-Day Exposure to Normobaric Hypoxia on the Cardiopulmonary Function of Rats.Current issues in molecular biology · 2025Article
- Sex Differences in Neurovascular Control: Implications for Obstructive Sleep Apnea.International journal of molecular sciences · 2023Review
- The forearm vascular response to sympathetic activation is attenuated in female, but not male, participants following acute intermittent hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Adrenergic control of skeletal muscle blood flow during chronic hypoxia in healthy males.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Neuromuscular and Muscle Tissue Hemodynamic Responses When Exposed to Normobaric Hypoxia during Lower-Body Fatiguing Muscle Actions.Journal of musculoskeletal & neuronal interactions · 2023Article
- Non-pharmacological interventions for vascular health and the role of the endothelium.European journal of applied physiology · 2022Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
In humans, the net effect of acute systemic hypoxia in quiescent skeletal muscle is vasodilation despite significant reflex increases in muscle sympathetic vasoconstrictor nerve activity. This vasodilation increases tissue perfusion and oxygen delivery to maintain tissue oxygen consumption. Although several mechanisms may be involved, we recently tested the roles of two endothelial-derived substances during conditions of sympathoadrenal blockade to isolate local vascular control mechanisms: nitric oxide (NO) and prostaglandins (PGs). Our findings indicate that 1) NO normally plays a role in regulating vascular tone during hypoxia independent of the PG pathway; 2) PGs do not normally contribute to vascular tone during hypoxia, however, they do affect vascular tone when NO is inhibited; 3) NO and PGs are not independently obligatory to observe hypoxic vasodilation when assessed as a response from rest to steady-state hypoxia; and 4) combined NO and PG inhibition abolishes hypoxic vasodilation in human skeletal muscle. When the stimulus is exacerbated via combined submaximal rhythmic exercise and systemic hypoxia to cause further red blood cell (RBC) deoxygenation, skeletal muscle blood flow is augmented compared with normoxic exercise via local dilator mechanisms to maintain oxygen delivery to active tissue. Data obtained in a follow-up study indicate that combined NO and PG inhibition during hypoxic exercise blunts augmented vasodilation and hyperemia compared with control (normoxic) conditions by ∼50%; however, in contrast to hypoxia alone, the response is not abolished, suggesting that other local substances are involved. Factors associated with greater RBC deoxygenation such as ATP release, or nitrite reduction to NO, or both likely play a role in regulating this response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.