Evidence map›Paper›PMID 26023068›Full record

ArticleScientific reports2015

RiboTALE: A modular, inducible system for accurate gene expression control.

Navneet Rai, Aura Ferreiro, Alexander Neckelmann, Amy Soon, Andrew Yao, Justin Siegel, Marc T Facciotti, Ilias Tagkopoulos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Mechanism of Ligand Binding to Theophylline RNA Aptamer.Journal of chemical information and modeling · 2024
    Article
  2. Understanding the Formation and Mechanism of Anticipatory Responses inInternational journal of molecular sciences · 2022
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Navneet RaiUC Davis Genome Center, University of California-Davis, Davis, CA, USA.
Aura FerreiroUC Davis Undergraduate Program, University of California-Davis, Davis, CA, USA.
Alexander NeckelmannUC Davis Undergraduate Program, University of California-Davis, Davis, CA, USA.
Amy SoonUC Davis Undergraduate Program, University of California-Davis, Davis, CA, USA.
Andrew Yao1] UC Davis Genome Center, University of California-Davis, Davis, CA, USA [2] Department of Biomedical Engineering, University of California-Davis, Davis, CA, USA.
Justin Siegel1] UC Davis Genome Center, University of California-Davis, Davis, CA, USA [2] Department of Biochemistry &Molecular Medicine, University of California-Davis, Davis, CA, USA [3] Department of Chemistry, University of California-Davis, Davis, CA, USA.
Marc T Facciotti1] UC Davis Genome Center, University of California-Davis, Davis, CA, USA [2] Department of Biomedical Engineering, University of California-Davis, Davis, CA, USA.
Ilias Tagkopoulos1] UC Davis Genome Center, University of California-Davis, Davis, CA, USA [2] Department of Computer Science, University of California-Davis, Davis, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A limiting factor in synthetic gene circuit design is the number of independent control elements that can be combined together in a single system. Here, we present RiboTALEs, a new class of inducible repressors that combine the specificity of TALEs with the ability of riboswitches to recognize exogenous signals and differentially control protein abundance. We demonstrate the capacity of RiboTALEs, constructed through different combinations of TALE proteins and riboswitches, to rapidly and reproducibly control the expression of downstream targets with a dynamic range of 243.7 ± 17.6-fold, which is adequate for many biotechnological applications.

Indexed as

Gene Expression RegulationGene Regulatory NetworksGenes, SyntheticBiotechnology

Identifiers

PMID26023068
PMCPMC4650599

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.