Evidence map›Paper›PMID 26022815›Full record

Trial reportJournal of the American College of Cardiology2015

Cardiopulmonary benefits of reducing indoor particles of outdoor origin: a randomized, double-blind crossover trial of air purifiers.

Renjie Chen, Ang Zhao, Honglei Chen, Zhuohui Zhao, Jing Cai, Cuicui Wang, Changyuan Yang, Huichu Li, Xiaohui Xu, Sandie Ha and 2 more

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American College of Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 96 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 5 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02238028 nacompletednot on this map

Short-term Cardiovascular Benefits of Wearing Particulate-filtering Respirators: a Randomized Controlled Crossover Trial Among Healthy Young Adults

TypeinterventionalSponsorFudan UniversityRan2014 to 2014Enrolled28ConditionsAutonomic Nervous System Imbalance, Blood Pressure, Inflammation, VasoconstrictionArmsWear respirator
NCT02239744 nacompletednot on this map

Cardiopulmonary Benefits of Reducing Indoor Particles of Outdoor Origin: a Randomized Double-blind Crossover Trial of Air Purifiers

TypeinterventionalSponsorFudan UniversityRan2014 to 2014Enrolled35ConditionsInflammation, Coagulation, Blood Pressure, Pulmonary FunctionArmsAir purifiers
NCT04563052 nacompletednot on this mapstarted 2020, after this paper: background citation

Measuring Knowledge and Behavior After an Educational Program on Air Pollution as a Health Risk Reduction Strategy

TypeinterventionalSponsorVillanova UniversityRan2020 to 2021Enrolled40ConditionsAir Pollution, Risk Reduction BehaviorsArmsEducational Program on Air Pollution as a Health Risk Reduction Strategy
3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 5 syntheses or guidelines pooled it, 263 citations in OpenAlex.

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  11. Effects of the Use of Air Purifier on Indoor Environment and Respiratory System among Healthy Adults.International journal of environmental research and public health · 2020
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  16. Health Benefits of Air Purification: A Systematic Review.Environment & health (Washington, D.C.) · 2026
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Renjie ChenSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Fudan University, Shanghai, China; Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China.
Ang ZhaoSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China.
Honglei ChenEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Zhuohui ZhaoSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China.
Jing CaiSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China.
Cuicui WangSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China.
Changyuan YangSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China.
Huichu LiSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China.
Xiaohui XuDepartment of Epidemiology, College of Public Health and Health Professional and College of Medicine, University of Florida, Gainesville, Florida.
Sandie HaDepartment of Epidemiology, College of Public Health and Health Professional and College of Medicine, University of Florida, Gainesville, Florida.
Tiantian LiInstitute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing, China.
Haidong KanSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Fudan University, Shanghai, China; Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China. Electronic address: haidongkan@gmail.com.
Fudan University · CNUniversity of Florida · USChinese Center For Disease Control and Prevention · CNNational Institutes of Health · US

Funding

Prospective studies on Parkinson's diseaseZIAES101986 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CHEN, HONGLEI · 2009 to 2016
$7.9M
Prospective studies on Parkinson's diseaseZ01ES101986 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CHEN, HONGLEI · 2006 to 2008
$1.2M
Intramural NIH HHS Z01 ES101986
6 · The paper itself

Abstract

backgroundIndoor exposure to fine particulate matter (PM2.5) from outdoor sources is a major health concern, especially in highly polluted developing countries such as China. Few studies have evaluated the effectiveness of indoor air purification on the improvement of cardiopulmonary health in these areas.

objectivesThis study sought to evaluate whether a short-term indoor air purifier intervention improves cardiopulmonary health.

methodsWe conducted a randomized, double-blind crossover trial among 35 healthy college students in Shanghai, China, in 2014. These students lived in dormitories that were randomized into 2 groups and alternated the use of true or sham air purifiers for 48 h with a 2-week washout interval. We measured 14 circulating biomarkers of inflammation, coagulation, and vasoconstriction; lung function; blood pressure (BP); and fractional exhaled nitric. We applied linear mixed-effect models to evaluate the effect of the intervention on health outcome variables.

resultsOn average, air purification resulted in a 57% reduction in PM2.5 concentration, from 96.2 to 41.3 μg/m3, within hours of operation. Air purification was significantly associated with decreases in geometric means of several circulating inflammatory and thrombogenic biomarkers, including 17.5% in monocyte chemoattractant protein-1, 68.1% in interleukin-1β, 32.8% in myeloperoxidase, and 64.9% in soluble CD40 ligand. Furthermore, systolic BP, diastolic BP, and fractional exhaled nitrous oxide were significantly decreased by 2.7%, 4.8%, and 17.0% in geometric mean, respectively. The impacts on lung function and vasoconstriction biomarkers were beneficial but not statistically significant.

conclusionsThis intervention study demonstrated clear cardiopulmonary benefits of indoor air purification among young, healthy adults in a Chinese city with severe ambient particulate air pollution. (Intervention Study on the Health Impact of Air Filters in Chinese Adults; NCT02239744).

Indexed as

AdultAir FiltersAir Pollution, IndoorBiomarkersCardiovascular DiseasesChinaCitiesCross-Over StudiesDouble-Blind MethodFemaleHealthy VolunteersHumansMaleParticulate MatterRespiratory Function TestsYoung AdultBiomarkersParticulate Matterair pollutionair purificationcardiovascular healthinterventionpulmonary healthrandomized controlled trial

Identifiers

PMID26022815
PMCPMC5360574
OpenAlexW409124881

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.