Evidence map›Paper›PMID 26022770›Full record

SynthesisNeurobiology of aging2015

Effects of noninvasive brain stimulation on cognitive function in healthy aging and Alzheimer's disease: a systematic review and meta-analysis.

Wan-Yu Hsu, Yixuan Ku, Theodore P Zanto, Adam Gazzaley

3 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 163 papers, 22 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 22 pooled it
19.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02596906 nacompletednot on this mapstarted 2016, after this paper: background citation

Brain and Cognitive Changes After Reasoning Training in Individuals With Cognitive Complaints

TypeinterventionalSponsorThe University of Texas at DallasRan2016 to 2018Enrolled22ConditionsMild Cognitive ImpairmentArmstDCS, Sham tDCS
NCT04118686 naunknown statusnot on this mapstarted 2017, after this paper: background citation

New Approaches for the Treatment of Early Stages of Cognitive Impairment in Neurodegenerative Diseases

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2017 to 2020Enrolled19ConditionsCognitive ImpairmentArmsCoRe software training plus non-invasive brain stimulation techniques (anodical tDCS / rTMS), CoRe software training plus sham non-invasive brain stimulation (sham tDCS/ sham rTMS)
NCT04889560 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Home-based Cognitive Treatment of Early Stages of Cognitive Impairment in Neurodegenerative Diseases: Home CoRe

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2021 to 2024Enrolled40ConditionsCognitive ImpairmentArmsExperimental group, Control group
3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 22 syntheses or guidelines pooled it, 327 citations in OpenAlex.

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  5. High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) on global cognitive function of elderly in mild to moderate Alzheimer's disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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  8. Treatment of epilepsy for people with Alzheimer's disease.The Cochrane database of systematic reviews · 2021
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  14. The role of noninvasive brain stimulation for behavioral and psychological symptoms of dementia: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Wan-Yu HsuDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Yixuan KuDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA; Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, Institue of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.
Theodore P ZantoDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Adam GazzaleyDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA; Department of Physiology and Psychiatry, University of California, San Francisco, San Francisco, CA, USA. Electronic address: adam.gazzaley@ucsf.edu.
University of California, San Francisco · US

Funding

Causal dynamics in neural networks underlying top-down modulationR01MH096861 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GAZZALEY, ADAM H · 2012 to 2015
$1.6M
NIMH NIH HHS R01 MH096861NIMH NIH HHS R01MH096861
6 · The paper itself

Abstract

The study aimed to evaluate the effects of noninvasive brain stimulation on cognitive function in healthy older adults and patients with Alzheimer's disease. A comprehensive literature search was performed on noninvasive stimulation studies published from January 1990 to November 2014 in Pubmed and Web of Science. Fourteen articles with a total of 331 participants were identified as studies with healthy older adults, and the mean effect size and 95% confidence interval were estimated. A significant effect size of 0.42 was found for the cognitive outcome. Further subgroup analyses demonstrated more prominent effects for studies delivering the stimulation before the execution of the task and studies applying multiple sessions of stimulation. To assess the effects of stimulation on Alzheimer's disease patients, 11 studies with a total of 200 patients were included in the analysis. A significant effect size of 1.35 was found for the cognitive outcomes. Subgroup analyses indicated more pronounced effects for studies applying the stimulation during the execution of the task compared with studies delivering the stimulation before the execution of the task. Noninvasive brain stimulation has a positive effect on cognitive function in physiological and pathological aging.

Indexed as

CognitionTranscranial Direct Current StimulationTranscranial Magnetic StimulationAgedAgingAlzheimer DiseaseDatabases, BibliographicFemaleHumansMaleMiddle AgedTreatment OutcomeAgingAlzheimer's disease (AD)Cognitive functionMeta-analysisNeuronal plasticityRepetitive transcranial magnetic stimulation (rTMS)Transcranial direct current stimulation (tDCS)

Identifiers

PMID26022770
PMCPMC4496249
OpenAlexW2133911471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.