Evidence map›Paper›PMID 26022739›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2015

Influence of non-cardiac comorbidities on outcome after percutaneous mitral valve repair: results from the German transcatheter mitral valve interventions (TRAMI) registry.

Christine S Zuern, Axel Bauer, Edith Lubos, Peter Boekstegers, Miriam Puls, Ralph Stephan V Bardeleben, Taoufik Ouarrak, Christian Butter, Holger Eggebrecht, Georg Nickenig and 3 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Functional status and quality of life after transcatheter mitral valve repair: a prospective cohort study and systematic review.Clinical research in cardiology : official journal of the German Cardiac Society · 2017
    Pooled it
  3. Trial
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  10. Early results of a real-world series with two transapical transcatheter mitral valve replacement devices.Clinical research in cardiology : official journal of the German Cardiac Society · 2021
    Article
  11. In-hospital outcomes of percutaneous mitral valve repair in patients with chronic obstructive pulmonary disease: insights from the national inpatient sample database.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2021
    Article
  12. Article
  13. Atrioventricular valve disease: challenges and achievements in percutaneous treatment.Clinical research in cardiology : official journal of the German Cardiac Society · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Christine S ZuernDeutsches Herzkompetenz Zentrum, Abteilung Kardiologie, Universitätsklinikum Tübingen, Medizinische Klinik III, Otfried-Müller-Str. 10, 72076, Tübingen, Germany. christine.zuern@gmx.de.
Axel BauerDeutsches Herzkompetenz Zentrum, Abteilung Kardiologie, Universitätsklinikum Tübingen, Medizinische Klinik III, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.
Edith LubosUniversitäres Herzzentrum Eppendorf, Hamburg, Germany.
Peter BoekstegersKlinikum Siegburg (Kardiologie und Angiologie), Siegburg, Germany.
Miriam PulsHerzzentrum, Georg-August-Universität Göttingen, Göttingen, Germany.
Ralph Stephan V BardelebenUniversitätsmedizin Mainz, 2. Med. Klinik, Mainz, Germany.
Taoufik OuarrakStiftung Institut für Herzinfarktforschung, Ludwigshafen, Germany.
Christian ButterHerzzentrum Brandenburg, Bernau, Germany.
Holger EggebrechtCardioangiologisches Centrum Bethanien, CCB, Frankfurt Am Main, Germany.
Georg NickenigUniversitätsklinikum Bonn (Med. Klinik und Poliklinik II), Bonn, Germany.
Ralph ZahnHerzzentrum, Ludwigshafen, Germany.
Jochen SengesStiftung Institut für Herzinfarktforschung, Ludwigshafen, Germany.
Andreas E MayDeutsches Herzkompetenz Zentrum, Abteilung Kardiologie, Universitätsklinikum Tübingen, Medizinische Klinik III, Otfried-Müller-Str. 10, 72076, Tübingen, Germany. Andreas.May@klinikum-memmingen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo investigate the influence of non-cardiac comorbidities on outcomes of patients enrolled in the German transcatheter mitral valve interventions (TRAMI) registry. METHODS AND

resultsIntrahospital and 30-day MACCE rates (death of all causes, stroke and myocardial infarction) of 828 patients from the TRAMI registry were stratified by the number of non-cardiac comorbidities. The following non-cardiac comorbidities were prospectively recorded in the registry: diabetes, renal insufficiency, extracardiac arteriopathy, chronic lung disease, neurological disease or malignancy on palliative care. The 375 (45.3 %) patients with multiple (≥2) non-cardiac comorbidities presented with higher NYHA classes, higher logistic Euroscores, higher levels of NT-proBNP and a shorter 6-min walk distance. Rates of intraprocedural death (0.3 vs. 0.0 %, p = 0.41) and intrahospital MACCE (3.6 vs. 1.9 %, p = 0.16) were not significantly higher in patients with multiple non-cardiac comorbidities, but 30-day MACCE rate was significantly enhanced (6.4 vs. 3.6 %, p = 0.049). However, both patient groups showed a similar clinical improvement after 30 days. Renal insufficiency was the only non-cardiac comorbidity which was independently associated with the 30-day MACCE rate.

conclusionsMitraClip device placement is feasible and safe in patients with multiple non-cardiac comorbidities resulting in a significant clinical improvement and acceptable intrahospital and 30-day event rates. Renal failure is an independent predictor of outcome.

Indexed as

AgedAged, 80 and overCardiac CatheterizationFemaleGermanyHospital MortalityHumansMaleMitral ValveMitral Valve InsufficiencyMyocardial InfarctionProspective StudiesRegistriesRenal InsufficiencyStrokeTime FactorsHeart failureMitraClipMitral valve regurgitationNon-cardiac comorbiditiesPercutaneous mitral valve repair

Identifiers

PMID26022739

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.