Evidence map›Paper›PMID 26022722›Full record

SynthesisJournal of nephrology2016

Treatment effect, adherence, and safety of high fluid intake for the prevention of incident and recurrent kidney stones: a systematic review and meta-analysis.

Wisit Cheungpasitporn, Sandro Rossetti, Keith Friend, Stephen B Erickson, John C Lieske

Registry-linked trialOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03645785 (Variation in Urine Electrolytes, pH and Specific Gravity Throughout the Day and the Effect of Increased Fluid Intake on Intra-Day Urine Composition), which is not on this map. Cited by 71 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 11 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03645785 nacompletednot on this mapstarted 2018, after this paper: background citation

Variation in Urine Electrolytes, pH and Specific Gravity Throughout the Day and the Effect of Increased Fluid Intake on Intra-Day Urine Composition

TypeinterventionalSponsorAdam Howe, MDRan2018 to 2019Enrolled23ConditionsHealthyArmsNormal fluid intake without true lemon, Double fluid intake plus 3 bottles of water with True Lemon
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 11 syntheses or guidelines pooled it, 135 citations in OpenAlex.

  1. Pooled it
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  9. Water for preventing urinary stones.The Cochrane database of systematic reviews · 2020
    Pooled it
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  11. Pooled it
  12. Trial
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  15. Article
  16. Article
  17. Article
  18. Lifestyle and Environment Aspects Challenging Kidney Health.Kidney & blood pressure research · 2026
    Review
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  20. Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Wisit CheungpasitpornDivision of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Sandro RossettiCardiorenal Department, Medical Affairs, Otsuka America Pharmaceutical, Inc., Princeton, NJ, USA.
Keith FriendCardiorenal Department, Medical Affairs, Otsuka America Pharmaceutical, Inc., Princeton, NJ, USA.
Stephen B EricksonDivision of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
John C LieskeDivision of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Lieske.john@mayo.edu.
Mayo Clinic · USOtsuka (United States) · US

Funding

VISUALIZATION AND PATHOPHYSIOLOGY OF RENAL STONE PRECURSOR LESIONSU54DK100227 · NIDDK · MAYO CLINIC ROCHESTER · PI LIESKE, JOHN C · 2013 to 2017
$6.3M
NIDDK NIH HHS U54 DK100227PHS HHS U54KD083908
6 · The paper itself

Abstract

backgroundThe objective of this systematic review and meta-analysis were to evaluate the effectiveness of high fluid intake for the prevention of incident and recurrent kidney stones, as well as its adherence and safety.

methodsA literature search was performed encompassing 1980 through July 2014. Studies that reported relative risks, odds ratios, or hazard ratios comparing the risk of kidney stone events in patients with high vs inadequate fluid intake were included. Pooled risk ratios (RRs) and 95 % confidence intervals (CIs) were calculated using a random-effect, generic inverse variance method.

resultsNine studies [2 randomized controlled trials (RCTs) with 269 patients; 7 observational studies with 273,685 individuals] were included in the meta-analysis. Pooled RRs of kidney stones in individuals with high-fluid intake were 0.40 (95 % CI 0.20-0.79) and 0.49 (0.34-0.71) in RCTs and observational studies, respectively. High fluid intake was significantly associated with reduced risk of recurrent kidney stones: RRs 0.40 (95 % CI 0.20-0.79) and 0.20 (0.09-0.44) in RCTs and observational studies, respectively. Adherence and safety data on high fluid intake treatment were limited; 1 RCT reported no withdrawals due to adverse events.

conclusionThis analysis demonstrated a significantly reduced risk of incident kidney stones among individuals with high fluid consumption. High fluid consumption also reduced the risk of recurrent kidney stones. Furthermore, the magnitude of risk reduction was high. Although increased water intake appears to be safe, future studies on its safety in patients with high risk of volume overload or hyponatremia may be indicated.

Indexed as

DrinkingPatient ComplianceChi-Square DistributionFemaleFluid TherapyHumansIncidenceKidney CalculiMaleOdds RatioRecurrenceRisk FactorsTreatment OutcomeUrinationFluid intakeHyponatremiaKidney stonesMeta-analysisWater

Identifiers

PMID26022722
PMCPMC4831051
OpenAlexW882890009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.