ReviewStem cell reviews and reports2015
Induced Pluripotent Stem Cells as a new Strategy for Osteogenesis and Bone Regeneration.
Review in Stem cell reviews and reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Stem cell-derived extracellular vesicles as a therapeutic for avascular necrosis: current status and future prospects.Regenerative medicine · 2025Review
- Murine iPSC-Loaded Scaffold Grafts Improve Bone Regeneration in Critical-Size Bone Defects.International journal of molecular sciences · 2024Article
- Experimental Early Stimulation of Bone Tissue Neo-Formation for Critical Size Elimination Defects in the Maxillofacial Region.Polymers · 2023Article
- 3D Bioprinting in Otolaryngology: A Review.Advanced healthcare materials · 2023Review
- Gene-repaired iPS cells as novel approach for patient withFrontiers in bioengineering and biotechnology · 2023Article
- Bone regeneration of induced pluripotent stem cells derived from peripheral blood cells in collagen sponge scaffolds.Journal of applied oral science : revista FOB · 2022Article
- Superior Alignment of Human iPSC-Osteoblasts Associated with Focal Adhesion Formation Stimulated by Oriented Collagen Scaffold.International journal of molecular sciences · 2021Article
- Article
- Direct Reprogramming of Mouse Fibroblasts into Functional Osteoblasts.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Can injection of adipose stem cells to non-union zone increase bone union? Experimental rat study.Joint diseases and related surgery · 2020Article
- Bacteriophage-based biomaterials for tissue regeneration.Advanced drug delivery reviews · 2019Review
- Article
- Adult Stem Cells for Bone Regeneration and Repair.Frontiers in cell and developmental biology · 2019Review
- Stimulation of Osteogenic Differentiation of Induced Pluripotent Stem Cells (iPSCs) Using Bioactive Glasses: AnFrontiers in bioengineering and biotechnology · 2019Article
- Bone physiology as inspiration for tissue regenerative therapies.Biomaterials · 2018Review
- Determining Osteogenic Differentiation Efficacy of Pluripotent Stem Cells by Telomerase Activity.Tissue engineering and regenerative medicine · 2018Article
- The paracrine effects of human induced pluripotent stem cells promote bone-like structures via the upregulation of BMP expression in a mouse ectopic model.Scientific reports · 2018Article
- The Biological Enhancement of Spinal Fusion for Spinal Degenerative Disease.International journal of molecular sciences · 2018Review
- From the Clinical Problem to the Basic Research-Co-Culture Models of Osteoblasts and Osteoclasts.International journal of molecular sciences · 2018Review
- Construction of human induced pluripotent stem cell-derived oriented bone matrix microstructure by using in vitro engineered anisotropic culture model.Journal of biomedical materials research. Part A · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Induced pluripotent stem (iPS) cells, possess high proliferation and differentiation ability, are now considered an attractive option for osteogenic differentiation and bone regeneration. In fact, recent discoveries have demonstrated that iPS cells can be differentiated into osteoblasts, suggesting that iPS cells have the potential to advance future bone regenerative therapies. Herein, we provide an overview of the recent findings on osteogenic characteristics and differentiation potential of iPS cells. In addition, we discuss current methods for inducing their specification towards osteogenic phenotype as well as in vivo evidence supporting the therapeutic benefit of iPS-derived osteoblasts. Finally, we describe recent findings regarding the use of iPS-derived cells for osteogenic differentiation and bone regeneration, which have indicated that these pluripotent cells represent an ideal tool for regenerative cell therapies and might contribute to the development of future bone tissue engineering.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.