Trial reportMedical principles and practice : international journal of the Kuwait University, Health Science Centre2015
Are Growing Pains Related to Vitamin D Deficiency? Efficacy of Vitamin D Therapy for Resolution of Symptoms.
Trial report in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Clinical Screening and Factors Influencing Growing Pain in Children with Recurrent Lower Limb Pain: A Controlled Study on Symptom Assessment and Motor Load.International journal of general medicine · 2026Article
- Risk factors associated with growth pain disorder in children: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Article
- Vitamin D deficiency and fatigue in children: an overlooked but modifiable factor?World journal of pediatrics : WJP · 2025Article
- Article
- Growing pains in Danish preschool children: a descriptive study.Scientific reports · 2024Article
- Prevalence of growing pains in a general paediatric OPD: A descriptive, observational and cross-sectional study.Journal of family medicine and primary care · 2023Article
- Clinical, laboratory characteristics and growth outcomes of children with growing pains.Scientific reports · 2022Article
- Application of bone metabolic parameters in the diagnosis of growing pains.Journal of clinical laboratory analysis · 2022Article
- Article
- Pain Severity and Vitamin D Deficiency in IBD Patients.Nutrients · 2019Article
- [Growing Pains : Cause, Significance and Treatment].Der Orthopade · 2019Review
- Growing pains: What do we know about etiology? A systematic review.World journal of orthopedics · 2019Article
- A pilot validation study of crowdsourcing systematic reviews: update of a searchable database of pediatric clinical trials of high-dose vitamin D.Translational pediatrics · 2017Article
- Growing Pains.Sports healthReview
- Restless legs syndrome and growing pains in childhood: understanding the link.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to investigate the 25-hydroxyvitamin D [25(OH)D] status of children with growing pains and to evaluate the efficacy of vitamin D treatment on the resolution of pain symptoms. SUBJECTS AND
methodsOne hundred and twenty children with growing pains were included in a prospective cohort study. Serum 25(OH)D and bone mineral levels were measured in all subjects at the time of enrollment. The pain intensity of those with vitamin D deficiency was measured using a pain visual analog scale (VAS). After a single oral dose of vitamin D, the pain intensity was remeasured by means of the VAS at 3 months. The 25(OH)D levels and VAS scores before and after oral vitamin D administration were compared by means of a paired Student's t test.
resultsIn the 120 children with growing pains, vitamin D insufficiency was noted in 104 (86.6%). Following vitamin D supplementation, the mean 25(OH)D levels increased from 13.4 ± 7.2 to 44.5 ± 16.4 ng/ml, the mean pain VAS score decreased from 6.8 ± 1.9 to 2.9 ± 2.5 cm (a mean reduction of -3.8 ± 2.1, p < 0.001) and the difference was statistically significant.
conclusionSupplementation with oral vitamin D resulted in a significant reduction in pain intensity among these children with growing pains who had hypovitaminosis D.
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