ArticleJournal of experimental botany2015
CYCD3 D-type cyclins regulate cambial cell proliferation and secondary growth in Arabidopsis.
Article in Journal of experimental botany, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
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- Endogenous Multilayer Control of Cambial Stem Cells and Its Consequences for Wood Formation.Plants (Basel, Switzerland) · 2026Review
- Comprehensive Analysis of Boron-Induced Changes in Cell Expansion and Phytohormone During Early Ovary Development in Pear (Plants (Basel, Switzerland) · 2025Article
- A transcriptional roadmap of the yearly growth cycle in Populus trees.The Plant cell · 2025Article
- Nitrogen-Driven Orchestration of Lateral Root Development: Molecular Mechanisms and Systemic Integration.Biology · 2025Review
- Comparative transcriptome analysis provides novel insights into the seed germination of Panax japonicus, an endangered species in China.BMC plant biology · 2024Article
- Developmental cues are encoded by the combinatorial phosphorylation of Arabidopsis RETINOBLASTOMA-RELATED protein RBR1.The EMBO journal · 2024Article
- A major role of class III HD-ZIPs in promoting sugar beet cyst nematode parasitism in Arabidopsis.PLoS pathogens · 2024Article
- Bulked Segregant RNA-Seq Reveals Different Gene Expression Patterns and Mutant Genes Associated with the Zigzag Pattern of Tea Plants (International journal of molecular sciences · 2024Article
- Functional characterization of D-type cyclins involved in cell division in rice.BMC plant biology · 2024Article
- The response of Arabidopsis to the apocarotenoid β-cyclocitric acid reveals a role for SIAMESE-RELATED 5 in root development and drought tolerance.PNAS nexus · 2023Article
- A Large-Scale Candidate-Gene Association Mapping for Drought Tolerance and Agronomic Traits in Sugarcane.International journal of molecular sciences · 2023Article
- Analysis of companion cell and phloem metabolism using a transcriptome-guided model of Arabidopsis metabolism.Plant physiology · 2023Article
- An Integration of Linkage Mapping and GWAS Reveals the Key Genes for Ear Shank Length in Maize.International journal of molecular sciences · 2022Article
- Combined transcriptome and metabolome analysis revealed pathways involved in improved salt tolerance of Gossypium hirsutum L. seedlings in response to exogenous melatonin application.BMC plant biology · 2022Article
- Review
- Study on the interaction preference between CYCD subclass and CDK family members at the poplar genome level.Scientific reports · 2022Article
- Overexpression ofInternational journal of molecular sciences · 2021Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major proportion of plant biomass is derived from the activity of the cambium, a lateral meristem responsible for vascular tissue formation and radial organ enlargement in a process termed secondary growth. In contrast to our relatively good understanding of the regulation of primary meristems, remarkably little is known concerning the mechanisms controlling secondary growth, particularly how cambial cell divisions are regulated and integrated with vascular differentiation. A genetic loss-of-function approach was used here to reveal a rate-limiting role for the Arabidopsis CYCLIN D3 (CYCD3) subgroup of cell-cycle genes in the control of cambial cell proliferation and secondary growth, providing conclusive evidence of a direct link between the cell cycle and vascular development. It is shown that all three CYCD3 genes are specifically expressed in the cambium throughout vascular development. Analysis of a triple loss-of-function CYCD3 mutant revealed a requirement for CYCD3 in promoting the cambial cell cycle since mutant stems and hypocotyls showed a marked reduction in diameter linked to reduced mitotic activity in the cambium. Conversely, loss of CYCD3 provoked an increase in xylem cell size and the expression of differentiation markers, showing that CYCD3 is required to restrain the differentiation of xylem precursor cells. Together, our data show that tight control of cambial cell division through developmental- and cell type-specific regulation of CYCD3 is required for normal vascular development, constituting part of a novel mechanism controlling organ growth in higher plants.
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