ArticleGenetics2015
Visualizing Molecular Functions and Cross-Species Activity of Sex-Peptide in Drosophila.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Correlated Gene Copy Number Changes in a Seminal Fluid Protein Network inbioRxiv : the preprint server for biology · 2025Article
- Gene age shapes functional and evolutionary properties of theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sex peptide receptor is not required for refractoriness to remating or induction of egg laying in Aedes aegypti.Genetics · 2024Article
- The Origin and Evolution of Sex Peptide and Sex Peptide Receptor Interactions.Molecular biology and evolution · 2024Article
- The Origin and Evolution of Sex Peptide and Sex Peptide Receptor Interactions.bioRxiv : the preprint server for biology · 2024Article
- Decoupled evolution of theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- The seminal odorant binding protein Obp56g is required for mating plug formation and male fertility ineLife · 2023Article
- Decoupled evolution of thebioRxiv : the preprint server for biology · 2023Article
- Male-female communication enhances release of extracellular vesicles leading to high fertility in Drosophila.Communications biology · 2022Article
- The evolution of sex peptide: sexual conflict, cooperation, and coevolution.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Interspecific introgression reveals a role of male genital morphology during the evolution of reproductive isolation in Drosophila.Evolution; international journal of organic evolution · 2021Article
- Article
- ThePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Female copulation song is modulated by seminal fluid.Nature communications · 2020Article
- Evolution of Reproductive Behavior.Genetics · 2020Review
- Divergence in sex peptide-mediated female post-mating responses inProceedings. Biological sciences · 2018Article
- Chemical Cues that Guide Female Reproduction in Drosophila melanogaster.Journal of chemical ecology · 2018Review
- The Drosophila Accessory Gland as a Model for Prostate Cancer and Other Pathologies.Current topics in developmental biology · 2017Review
- Evolution of sex-peptide in Drosophila.Fly · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila melanogaster sex-peptide (melSP) is a seminal fluid component that induces postmating responses (PMR) of females via the sex-peptide receptor (SPR) . Although SP orthologs are found in many Drosophila species, their functions remain poorly characterized. It is unknown whether SP functions are conserved across species or rather specific to each species. Here, we developed a GFP-tagged melSP (G-SP) and used it to visualize cross-species binding activity to the female reproductive system of various species. First we demonstrated that ectopically expressed G-SP induced PMR in D. melanogaster females and bound to the female reproductive system, most notably to the common oviduct. No binding occurred in the females lacking SPR, indicating that G-SP binding was dependent on SPR. Next we tested whether G-SP binds to the common oviducts from 11 Drosophila species using dissected reproductive tracts. The binding was observed in six species belonging to the D. melanogaster species group, but not to those outside the group. Injection of melSP reduced the receptivity of females belonging to the D. melanogaster species group, but not of those outside the group, being consistent with the ability to bind G-SP. Thus the SP-mediated PMR appears to be limited to this species group. SPR was expressed in the oviducts at high levels in this group; therefore, we speculate that an enhanced expression of SPR in the oviduct was critical to establish the SP-mediated PMR during evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.