ArticleMolecules and cells2015
Lipoteichoic acid isolated from Lactobacillus plantarum inhibits melanogenesis in B16F10 mouse melanoma cells.
Article in Molecules and cells, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Dietary heat-killedVeterinary and animal science · 2026Article
- The Potential Anticancer Mechanisms of Probiotics: A Comprehensive Review.Probiotics and antimicrobial proteins · 2026Review
- The dual role of lipoteichoic acid: from immune modulation to therapeutic applications in disease treatment.Inflammopharmacology · 2026Review
- Anti-melanogenic and Antioxidant Activities of Lactiplantibacillus plantarum Strains in Skin Cells via the CREB/MITF and Nrf2/HO-1 Pathways.Probiotics and antimicrobial proteins · 2025Article
- Targeting Melanogenesis with Postbiotics: An Integrated Zebrafish-Based Assessment ofMolecules (Basel, Switzerland) · 2025Article
- Microbiome and Postbiotics in Skin Health.Biomedicines · 2025Review
- Beneficial effect of heat-killed Lactiplantibacillus plantarum L-137 on intestinal barrier function of rat small intestinal epithelial cells.Scientific reports · 2024Article
- Skin Deep: The Potential of Microbiome Cosmetics.Journal of microbiology (Seoul, Korea) · 2024Review
- Article
- Applications of Probiotic Constituents in Cosmetics.Molecules (Basel, Switzerland) · 2023Review
- Anti-Melanogenic and Antioxidant Activity ofInternational journal of molecular sciences · 2023Article
- Investigation of phenyllactic acid as a potent tyrosinase inhibitor produced by probiotics.Current research in food science · 2023Article
- Heat-KilledAntioxidants (Basel, Switzerland) · 2022Article
- Deoxyvasicinone with Anti-Melanogenic Activity from Marine-DerivedMarine drugs · 2022Article
- An Update on the Effectiveness of Probiotics in the Prevention and Treatment of Cancer.Life (Basel, Switzerland) · 2022Review
- Comparative Insights into the Skin Beneficial Properties of ProbioticBioMed research international · 2022Article
- Antioxidant and Antimelanogenic Activities of Kimchi-DerivedJournal of microbiology and biotechnology · 2021Article
- Anti-Pigmentary Natural Compounds and Their Mode of Action.International journal of molecular sciences · 2021Review
- Combined targeting of vascular endothelial growth factor C (VEGFC) and P65 using miR-27b-3p agomir and lipoteichoic acid in the treatment of gastric cancer.Journal of gastrointestinal oncology · 2021Article
- Korean Red Ginseng extract ameliorates melanogenesis in humans and induces antiphotoaging effects in ultraviolet B-irradiated hairless mice.Journal of ginseng research · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipoteichoic acid (LTA) is a major component of the cell wall of Gram-positive bacteria. Its effects on living organisms are different from those of lipopolysaccharide (LPS) found in Gram-negative bacteria. LTA contributes to immune regulatory effects including anti-aging. In this study, we showed that LTA isolated from Lactobacillus plantarum (pLTA) inhibited melanogenesis in B16F10 mouse melanoma cells. pLTA reduced the cellular activity of tyrosinase and the expression of tyrosinase family members in a dose-dependent manner. The expression of microphthalmia-associated transcription factor (MITF), a key factor in the synthesis of melanin, was also decreased by pLTA. Further, we showed that pLTA activated melanogenesis signaling, such as extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3-kinse (PI3K)/AKT. In addition, the expression of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and HuR, which are important RNA-binding proteins (RBPs), was reduced. pLTA likely degrades MITF via regulation of melanogenic signaling and RNA stability of melanogenic proteins, resulting in the reduction of melanin. Thus, our data suggest that pLTA has therapeutic potential for treating hyperpigmentation disorders and can also be used as a cosmetic whitening agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.